Rare Cancer News

Unread items (100)

1 2 3 ... 28

Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst.

Fetched: January 31st, 2010, 3:49pm CST

Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst.

Indian J Pathol Microbiol. 2010 Jan-Mar;53(1):190-2

Authors: Jena M, Shariff S, Jeyachandran P

PMID: 20090274 [PubMed - in process]

Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma.

Fetched: January 31st, 2010, 3:49pm CST

Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma.

Pathol Res Pract. 2009;205(12):838-42

Authors: Weiler C, Reu S, Zengel P, Kirchner T, Ihrler S

The differential diagnosis between benign salivary oncocytoma (ONC) and low-grade malignant acinic cell carcinoma (ACC) can be difficult due to a significant histomorphological overlap of the structural and cytological presentation of both tumor types. To the best of our knowledge a comprehensive study comparing (immuno-)histological markers in cases of difficult differential diagnosis between ONC and ACC has not yet been performed. We investigated a panel of different immunohistochemical (CK5/6, CK14, CK7, CK18, p63 and Ki67) and histochemical (PAS, alpha-amylase) markers in 12 cases of ONC and 19 cases of ACC. The statistically significant stronger expression of CK7 in ONC and stronger expression of PAS and alpha-amylase in ACC in routine practice each is hampered by a pronounced overlap between both tumor groups. The obligate presence of an additional small basal cell component in all cases of ONC, demonstrable with p63 and CK5/6, enables a straightforward distinction from ACC, being constantly devoid of a basal cell component. Unexpectedly, CK14 is not a suitable marker for a reliable proof of these basal cells. The detection of this basal cell component in ONC in routine Hematoxylin-eosin stain is difficult and in some cases not possible; therefore, immunohistochemistry with p63 or CK5/6 is recommended for selected cases.

PMID: 19646823 [PubMed - indexed for MEDLINE]

[A case of acinar cell carcinoma of pancreas with liver metastases treated effectively by s-1.]

Fetched: January 21st, 2010, 6:02pm CST

[A case of acinar cell carcinoma of pancreas with liver metastases treated effectively by s-1.]

Gan To Kagaku Ryoho. 2010 Jan;37(1):127-9

Authors: Morishima K, Hyodo M, Nihei Y, Sata N, Yasuda Y

A 65-year-old man underwent a total gastrectomy and distal pancreatectomy for acinar cell carcinoma of the pancreas. Multiple metastatic liver lesions were found one year postoperatively. He was treated with S-1 chemotherapy over 34 months, and the tumors significantly reduced in size without severe side effects. Four years after surgery, the liver metastases increased in size, associated with pain especially in the right upper quadrant. We then performed right hepatectomy. Peritoneal dissemination and multiple lungmetastases were found 8 months after liver resection. Acinar cell carcinoma of the pancreas is a rare and highly malignant tumor, and there are few reports regarding treatment with chemotherapy. Herein, we report a case with multiple liver metastases which were controlled by systemic chemotherapy using S -1.

PMID: 20087046 [PubMed - in process]

Promotion of beta-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells.

Fetched: January 20th, 2010, 9:02am CST

Promotion of beta-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells.

Biomed Pharmacother. 2010 Jan 4;

Authors: Kawakami M, Hirayama A, Tsuchiya K, Ohgawara H, Nakamura M, Umezawa K

We previously found that conophylline, an alkaloid isolated from the leaves of Ervatamia microphylla, induced beta-cell differentiation in rat pancreatic acinar carcinoma cells and in cultured fetal rat pancreatic tissue and that it also decreased the blood glucose level in streptozotocin-treated fetal rats. In the present research, we looked into the effect of conophylline on the differentiation of newborn pig pancreatic endocrine cells into insulin-secreting cells. Conophylline potentiated the differentiation of monolayer cells into insulin-producing cells in the presence of nicotinamide in 3weeks. Next we prepared islet-like cell clusters (ICC). Cononophylline together with nicotinamide also increased the number of insulin-producing cells and the insulin content in ICC in 3-6weeks. The ICC thus prepared were sensitive to the glucose concentration for the insulin secretion. Conophylline increased the mRNA expression of PDX-1, neurogenin3, neuroD/Beta2, and insulin in ICC. Thus, the vinca alkaloid conophylline potentiated beta-cell differentiation in porcine pancreatic endocrine-rich cells in cluster cultures. Pig pancreatic cells are practical candidate for use in transplantation therapy. Conophylline may thus be useful for the large-scale preparation of porcine insulin-producing cells for the regeneration therapy of type-1 diabetes mellitus.

PMID: 20079600 [PubMed - as supplied by publisher]

Mixed adenocarcinomas of the lung: place in new proposals in classification, mandatory for target therapy.

Fetched: January 20th, 2010, 9:02am CST

Mixed adenocarcinomas of the lung: place in new proposals in classification, mandatory for target therapy.

Arch Pathol Lab Med. 2010 Jan;134(1):55-65

Authors: Chilosi M, Murer B

CONTEXT: Lung cancer is one of the most frequent and lethal malignant neoplasms, but knowledge regarding the molecular basis of its pathogenesis is far from complete due to the striking diversity of different forms. The current lung cancer classification (World Health Organization 2004) can efficiently distinguish clinically relevant major subtypes (small cell and non-small cell carcinomas), but its results are partly inadequate when facing prognostic and therapeutic decisions for non-small cell carcinomas, especially for the group of tumors classified as adenocarcinoma. Lung adenocarcinoma comprises a heterogeneous group of tumors characterized by diverse morphologic features and molecular pathogenesis. The category of mixed adenocarcinomas includes most adenocarcinomas (approximately 80%) and, according to World Health Organization criteria, is defined by the occurrence of a mixed array of different patterns (acinar, papillary, bronchioloalveolar, solid with mucin). The histologic recognition of mixed adenocarcinoma is subjective and cannot consistently discriminate between responders and nonresponders to new targeted therapies (eg, tyrosine kinase inhibitors). Diagnostic problems are mainly related to the poor reproducibility of histologic criteria, especially when applied in small biopsies and cytology, and to the difficulty in assigning each form to a precisely defined entity, as needed by updated therapeutic approaches. In this evolving scenario, pathologists face new challenging diagnostic roles that include not only the precise morphologic definition of carcinoma subtypes but also their molecular characterization. OBJECTIVE: To use a comprehensive critical analysis reconciling the overwhelming variety of biologic, morphologic, molecular, and clinical data to define new classification schemes for lung adenocarcinoma. DATA SOURCES: Scientific literature and personal data were used. CONCLUSIONS: A new classification approach should redefine lung adenocarcinoma heterogeneity reconciling classic morphology, immunophenotypic and molecular features of neoplastic cells, and also relevant information provided by stem cell biology. This approach, which has been already successfully applied in World Health Organization classification of other tumors, could improve the recognition of new reproducible profiles for adenocarcinomas, more closely and reproducibly related to clinical features and response to specific therapies, limiting the use of "wastebasket" categories such as mixed adenocarcinoma.

PMID: 20073606 [PubMed - in process]

Permalink for 'Pancreatic-type mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from the stomach: a report of an extremely rare case.'

Pancreatic-type mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from the stomach: a report of an extremely rare case.

Fetched: January 20th, 2010, 9:02am CST

Pancreatic-type mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from the stomach: a report of an extremely rare case.

Med Mol Morphol. 2009 Sep;42(3):167-74

Authors: Kusafuka K, Bando E, Muramatsu K, Ito H, Tanizawa Y, Kawamura T, Mochizuki T, Terashima M, Nakajima T

An extremely rare case of mixed acinar-endocrine carcinoma (MAEC) arising from the stomach in a 56-year-old Japanese woman is herein presented. An endoscopic examination and computed tomography showed a protruding gastric tumor and a large extragastric mass, respectively. Macroscopic observation on the surgical specimen revealed the extragastric cystic mass was continued to the intragastric tumor. Histologically, the intragastric tumor consisted of large or small solid nests with acinar appearance. The cancer cells had an ovoid nuclei and polygonal cytoplasm, which was frequently amphophilic. Immunohistochemical examination showed that the cancer cells were positive for chromogranin-A, synaptophysin, alpha-amylase, lipase, and alpha-fetoprotein (AFP) but were negative for CD56, insulin, and other hormones. Ultrastructurally, the cancer cells contained 500-nm electron-lucent zymogen granules and 230-nm electron-dense neuroendocrine granules. This tumor was finally diagnosed to be MAEC with AFP production of the stomach. Although no ectopic pancreas was found in the stomach, this tumor may originate from ectopic pancreas. As another theory, it is possible for this tumor to originate from the pluripotent stem cells in the stomach. A gastric MAEC with AFP production has not been reported previously.

PMID: 19784744 [PubMed - indexed for MEDLINE]

Permalink for 'Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.'

Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.

Fetched: January 20th, 2010, 9:02am CST

Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.

Mol Cancer Res. 2009 Sep;7(9):1572-81

Authors: Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura K

Serine protease inhibitor, Kazal type 1 (SPINK1) is expressed not only in normal human pancreatic acinar cells but also in a variety of pancreatic ductal neoplasms. There are structural similarities between SPINK1 and epidermal growth factor (EGF). Hence, we hypothesized that SPINK1 binds to EGF receptor (EGFR) to activate its downstream signaling. We first showed that SPINK1 induced proliferation of NIH 3T3 cells and pancreatic cancer cell lines. We showed that SPINK1 coprecipitated with EGFR in an immunoprecipitation experiment and that the binding affinity of SPINK1 to EGFR was about half of that of EGF using quartz-crystal microbalance (QCM) technique. As expected, EGFR and its downstream molecules, signal transducer and activator of transcription 3, v-Akt murine thymoma viral oncogene homologue, and extracellular signal-regulated kinase 1/2, were phosphorylated by SPINK1 as well as EGF. To determine which pathway is the most important for cell growth, we further analyzed the effect of inhibitors. Growth stimulation by EGF or SPINK1 was completely inhibited by EGFR and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor but not by Janus-activated kinase and phosphoinositide 3-kinase inhibitors. To further analyze the clinical importance of SPINK1 in the development of pancreatic cancer, we examined the expression of SPINK1 and EGFR in pancreatic tubular adenocarcinomas and pancreatic intraepithelial neoplasm. Both SPNK1 and EGFR were coexpressed not only in the early stage of cancer, PanIN-1A, but also in advanced stages. Taken together, these results suggest that SPINK1 stimulates the proliferation of pancreatic cancer cells through the EGFR/mitogen-activated protein kinase cascade.

PMID: 19737965 [PubMed - indexed for MEDLINE]

A prognostic index for predicting lymph node metastasis in minor salivary gland cancer.

Fetched: January 20th, 2010, 9:02am CST

A prognostic index for predicting lymph node metastasis in minor salivary gland cancer.

Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):169-75

Authors: Lloyd S, Yu JB, Ross DA, Wilson LD, Decker RH

PURPOSE: Large studies examining the clinical and pathological factors associated with nodal metastasis in minor salivary gland cancer are lacking in the literature. METHODS AND MATERIALS: Using the Surveillance, Epidemiology, and End Results (SEER) database, we identified 2,667 minor salivary gland cancers with known lymph node status from 1988 to 2004. Univariate and multivariate analyses were conducted to identify factors associated with the use of neck dissection, the use of external beam radiation therapy, and the presence of cervical lymph node metastases. RESULTS: Four hundred twenty-six (16.0%) patients had neck nodal involvement. Factors associated with neck nodal involvement on univariate analysis included increasing age, male sex, increasing tumor size, high tumor grade, T3-T4 stage, adenocarcinoma or mucoepidermoid carcinomas, and pharyngeal site of primary malignancy. On multivariate analysis, four statistically significant factors were identified, including male sex, T3-T4 stage, pharyngeal site of primary malignancy, and high-grade adenocarcinoma or high-grade mucoepidermoid carcinomas. The proportions (and 95% confidence intervals) of patients with lymph node involvement for those with 0, 1, 2, 3, and 4 of these prognostic factors were 0.02 (0.01-0.03), 0.09 (0.07-0.11), 0.17 (0.14-0.21), 0.41 (0.33-0.49), and 0.70 (0.54-0.85), respectively. Grade was a significant predictor of metastasis for adenocarcinoma and mucoepidermoid carcinoma but not for adenoid cystic carcinoma. CONCLUSIONS: A prognostic index using the four clinicopathological factors listed here can effectively differentiate patients into risk groups of nodal metastasis. The precision of this index is subject to the limitations of SEER data and should be validated in further clinical studies.

PMID: 19386433 [PubMed - indexed for MEDLINE]

[CT features of parotid tumors: an analysis of 133 cases]

Fetched: December 27th, 2009, 9:49am CST

[CT features of parotid tumors: an analysis of 133 cases]

Ai Zheng. 2007 Nov;26(11):1263-7

Authors: Lu YC, Fan WJ, Shen JX, Xiao P

BACKGROUND & OBJECTIVE: Most parotid tumors grow slowly. It is difficult to evaluate their malignancy. This study was to analyze the CT features of parotid tumors. METHODS: CT images of 133 patients with 157 lesions of parotid tumors, confirmed by histopathology, were reviewed. The location, contour, margin, enhancing type, necrosis and liquefaction, and adjacent structure involvement were analyzed. RESULTS: Among the 157 lesions, 110 (70.1%) were benign tumors, 18 (11.5%) were borderline tumors, and 29 (18.5%) were malignant tumors; 80 (72.7%) benign lesions and 14 (77.8%) borderline lesions located in the superficial lobe, whereas 7 (24.1%) malignant lesions located in the deep lobe and 10 (34.5%) in both the superficial lobe and the deep lobe; 99 (90.0%) benign lesions had sharp margins, 8 (44.4%) borderline lesions had sharp margins and 10 (55.6%) had partly unsharp margins, 10 (34.5%) malignant lesions had partly unsharp margins and 11 (37.9%) had unsharp margins. Most benign lesions were round (68/110, 61.8%) or oval (23/110, 20.9%), while malignant lesions were often irregular (14/29, 48.3%). Eleven lesions, including 2 borderline tumors and 9 malignant tumors, involved the adjacent subcutaneous fat. All the lesions which involved the bed of parotid gland were malignant. No benign tumor involved adjacent structures. CONCLUSION: On CT images, a parotid tumor located in the superficial lobe, with a round or oval contour and sharp margin, is more likely to be a benign tumor; otherwise, it might be a malignant tumor.

PMID: 17991330 [PubMed - indexed for MEDLINE]

An Update of the Gleason Grading System.

Fetched: December 22nd, 2009, 8:01am CST

An Update of the Gleason Grading System.

J Urol. 2009 Dec 12;

Authors: Epstein JI

PURPOSE: An update is provided of the Gleason grading system, which has evolved significantly since its initial description. MATERIALS AND METHODS: A search was performed using the MEDLINE(R) database and referenced lists of relevant studies to obtain articles concerning changes to the Gleason grading system. RESULTS: Since the introduction of the Gleason grading system more than 40 years ago many aspects of prostate cancer have changed, including prostate specific antigen testing, transrectal ultrasound guided prostate needle biopsy with greater sampling, immunohistochemistry for basal cells that changed the classification of prostate cancer and new prostate cancer variants. The system was updated at a 2005 consensus conference of international experts in urological pathology, under the auspices of the International Society of Urological Pathology. Gleason score 2-4 should rarely if ever be diagnosed on needle biopsy, certain patterns (ie poorly formed glands) originally considered Gleason pattern 3 are now considered Gleason pattern 4 and all cribriform cancer should be graded pattern 4. The grading of variants and subtypes of acinar adenocarcinoma of the prostate, including cancer with vacuoles, foamy gland carcinoma, ductal adenocarcinoma, pseudohyperplastic carcinoma and small cell carcinoma have also been modified. Other recent issues include reporting secondary patterns of lower and higher grades when present to a limited extent, and commenting on tertiary grade patterns which differ depending on whether the specimen is from needle biopsy or radical prostatectomy. Whereas there is little debate on the definition of tertiary pattern on needle biopsy, this issue is controversial in radical prostatectomy specimens. Although tertiary Gleason patterns are typically added to pathology reports, they are routinely omitted in practice since there is no simple way to incorporate them in predictive nomograms/tables, research studies and patient counseling. Thus, a modified radical prostatectomy Gleason scoring system was recently proposed to incorporate tertiary Gleason patterns in an intuitive fashion. For needle biopsy with different cores showing different grades, the current recommendation is to report the grades of each core separately, whereby the highest grade tumor is selected as the grade of the entire case to determine treatment, regardless of the percent involvement. After the 2005 consensus conference several studies confirmed the superiority of the modified Gleason system as well as its impact on urological practice. CONCLUSIONS: It is remarkable that nearly 40 years after its inception the Gleason grading system remains one of the most powerful prognostic factors for prostate cancer. This system has remained timely because of gradual adaptations by urological pathologists to accommodate the changing practice of medicine.

PMID: 20006878 [PubMed - as supplied by publisher]

Pancreatic tumors in children and adolescents: The Italian TREP project experience.

Fetched: December 22nd, 2009, 8:01am CST

Pancreatic tumors in children and adolescents: The Italian TREP project experience.

Pediatr Blood Cancer. 2009 Dec 8;

Authors: Dall'igna P, Cecchetto G, Bisogno G, Conte M, Chiesa PL, D'Angelo P, De Leonardis F, De Salvo G, Favini F, Ferrari A,

INTRODUCTION: Malignant pancreatic tumors are exceedingly rare in pediatric age and their clinical features and treatment usually go unappreciated by most pediatric oncologists and surgeons. METHODS: From January 2000 to July 2009, 21 patients <18 years old with pancreatic tumors were prospectively registered in the Italian cooperative TREP project dedicated to very rare pediatric tumors. RESULTS: Tumor types were 4 pancreatoblastomas, 2 pancreatic carcinomas, 3 neoplasms of the endocrine pancreas, and 12 solid pseudopapillary tumors. Three of the four patients with pancreatoblastoma had advanced disease at diagnosis and were given chemotherapy; at the time of this report, three patients were alive in first remission, while one died due to treatment toxicity. Both the cases of pancreatic carcinoma had the acinar cell subtype and successfully underwent pancreaticoduodenectomy with complete tumor resection, remaining without evidence of disease at the time of this analysis. The histological diagnoses of the three endocrine tumors were a malignant islet cell tumor, a gastrinoma, and a well-differentiated tumor. All 12 patients with solid pseudopapillary tumors underwent complete tumor resection and were given no adjuvant treatment; 11 were alive in first remission, while one experienced a local and distant relapse 5 years after diagnosis. CONCLUSIONS: Surgery remains the keystone of treatment for pancreatic tumors in pediatric age as in adults. The TREP project shows that prospective cooperative studies are feasible even for such very rare tumors as these and may serve as a model for developing international cooperative schemes. Pediatr Blood Cancer (c) 2009 Wiley-Liss, Inc.

PMID: 19998473 [PubMed - as supplied by publisher]

[Case of pulmonary adenocarcinoma with co-existing pulmonary actinomycosis in one region of the lung]

Fetched: December 22nd, 2009, 8:01am CST

[Case of pulmonary adenocarcinoma with co-existing pulmonary actinomycosis in one region of the lung]

Nihon Kokyuki Gakkai Zasshi. 2009 Sep;47(9):823-7

Authors: Ide S, Sawai T, Kaku N, Nagayoshi Y, Soda H, Kohno S

A 64-year-old man presented with chronic cough. Chest CT revealed a nodular shadow with cavitation in the right S6. Seven months after his first examination, the nodular shadow had gradually increased, so flexible fiberoptic bronchoscopy was performed. The results of bronchial brushing and aspiration cytology were negative, however, gram-stained smear of the bronchial aspirate revealed many gram-positive rods with branching filamentous hyphae and culture of the bronchial aspirate was positive for the Actinomyces species. On a diagnosis of pulmonary actinomycosis, 1500 mg of oral amoxicillin was initiated. After 4 months of treatment, the right S6 nodule size was unchanged and the level of CYFRA in serum was elevated. Therefore, video-assisted thoracic surgery (VATS) was performed. A histological examination of the resected tumor showed papillary and acinar adenocarcinoma. The common radiological features in patients with pulmonary actinomycosis are nodules, mass formation and cavitation. Pulmonary actinomycosis requires differentiation from lung cancer. Although lung cancer with coexisting pulmonary actinomycosis is rare, clinicians should take into consideration the fact that lung cancer and pulmonary actinomycosis can co-exist in the same patient.

PMID: 19827588 [PubMed - indexed for MEDLINE]

Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.

Fetched: December 22nd, 2009, 8:01am CST

Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.

Am J Surg Pathol. 2009 Dec;33(12):1752-64

Authors: Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD

The pathologic classification of nonsmall cell lung cancer (NSCLC) is evolving. Lung adenocarcinoma is morphologically heterogeneous, with mixtures of acinar, papillary, bronchioloalveolar, and solid patterns in more than 80% of cases. In case of synchronous or metachronous multiple NSCLC, the distinction of intrapulmonary metastases from independent primary tumors is of great clinical importance as it influences staging and potentially the therapeutic strategy. Here we took advantage of a cohort of 20 patients with 42 multiple NSCLC tumors (24 potential pair comparisons) that were annotated molecularly using genomic and mutational profiling to evaluate the value of comprehensive histologic assessment in this setting. Using the Martini-Melamed criteria, paired tumors were characterized as multiple primary NSCLCs in 21 cases and as intrapulmonary metastases in 3 cases. Genomic and mutational data led to a diagnosis of multiple primaries in 14 cases and of metastases in 8 cases; 2 cases could not be assessed. This molecular characterization contradicted the Martini-Melamed diagnosis in 7 (32%) of the 22 assessable comparisons. Adenocarcinoma was found in 32 (76%) of the 42 tumors. After review in a blinded fashion, semiquantitative comprehensive histologic assessment of paired tumors was different in 16 and similar in 8 paired tumors. We found that comparing adenocarcinomas is a complex issue that requires assessment not only of percentages of the histologic subtypes, but also the recording of additional histologic details such as cytologic features, patterns of stroma, necrosis, discrete nodularity versus miliary growth and variants such as clear cell, signet ring, mucinous, and fetal patterns. We also found that paired squamous cell carcinomas could be compared based on histologic subtyping in addition to cytologic and stromal characteristics. Considering histologically different tumors as multiple primaries, and similar tumors as metastases, comprehensive histologic subtyping was consistent with the molecular characterization in 20 (91%) of the 22 pairs comparisons. In summary, based on a well characterized cohort with detailed clinical, pathologic and molecular data, we found comprehensive histologic assessment is a powerful tool that seems to be a promising way to determine whether multiple lung adenocarcinomas or squamous cell carcinomas are metastatic or multiple primaries. This has great clinical implications for staging and therapeutic management of lung cancer patients with multiple tumors. Given its high correlation with molecular characterization of such tumors, it may provide a much cheaper and faster method to address this problem.

PMID: 19773638 [PubMed - indexed for MEDLINE]

Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells.

Fetched: December 22nd, 2009, 8:01am CST

Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells.

Int J Oncol. 2009 Oct;35(4):823-8

Authors: Pan Z, Erkan M, Streit S, Friess H, Kleeff J

As a molecular chaperone, GRP94 is the most abundant glycoprotein in the endoplasmic reticulum, playing an important role in maintaining cellular homeostasis. Here, we investigated the expression and the role of GRP94 in regulating cell growth and apoptosis in pancreatic cancer cells. GRP94 mRNA levels were analyzed by QRT-PCR. Immunohistochemistry was performed to localize GRP94 in tissues of the normal pancreas (n=20), chronic pancreatitis (n=20) and pancreatic ductal adenocarcinoma (n=44). Silencing of GRP94 expression was carried out by transfection with specific siRNA oligonucleotides. Apoptosis was induced by treatment with actinomycin D. Compared to normal pancreatic tissues, median mRNA levels of GRP94 were 1.5- and 3.7-fold (p<0.05) lower in chronic pancreatitis and pancreatic cancer tissues, respectively. GRP94 protein was strongly expressed in normal acinar cells and moderately expressed in normal ductal cells. GRP94 expression was lost in 48% of the cancer cases. Moderate or strong staining in cancer cells was observed in 32 and 20% of pancreatic cancer tissues, respectively. Silencing GRP94 by siRNA increased apoptosis of pancreatic cancer cells in vitro. Patients with higher than the median expression have a tendency for a worsened survival. When the small number of patients with the highest expression (n=3) were compared with the rest of the group (n=41), the survival difference was significantly worse (5 vs. 18 months, respectively, p=0.006). Down-regulation of GRP94 decreases apoptosis resistance in pancreatic cancer cells. Clinically, patients with high GRP94 expression show a tendency for a worsened survival.

PMID: 19724918 [PubMed - indexed for MEDLINE]

Permalink for 'The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.'

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

Fetched: December 22nd, 2009, 8:01am CST

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

J Pathol. 2009 Oct;219(2):205-13

Authors: Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I

Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are associated with major changes in cell differentiation. These changes may be at the basis of the increased risk for PDAC among patients with chronic pancreatitis. Polycomb proteins are epigenetic silencers expressed in adult stem cells; up-regulation of Polycomb proteins has been reported to occur in a variety of solid tumours such as colon and breast cancer. We hypothesized that Polycomb might play a role in preneoplastic states in the pancreas and in tumour development/progression. To test these ideas, we determined the expression of PRC1 complex proteins (Bmi1 and Ring1b) during pancreatic development and in pancreatic tissue from mouse models of disease: acute and chronic pancreatic injury, duct ligation, and in K-Ras(G12V) conditional knock-in and caerulein-treated K-Ras(G12V) mice. The study was extended to human pancreatic tissue samples. To obtain mechanistic insights, Bmi1 expression in cells undergoing in vitro exocrine cell metaplasia and the effects of Bmi1 depletion in an acinar cancer cell line were studied. We found that Bmi1 and Ring1B are expressed in pancreatic exocrine precursor cells during early development and in ductal and islet cells-but not acinar cells-in the adult pancreas. Bmi1 expression was induced in acinar cells during acute injury, in acinar-ductal metaplastic lesions, as well as in pancreatic intraepithelial neoplasia (PanIN) and PDAC. In contrast, Ring1B expression was only significantly and persistently up-regulated in high-grade PanINs and in PDAC. Bmi1 knockdown in cultured acinar tumour cells led to changes in the expression of various digestive enzymes. Our results suggest that Bmi1 and Ring1B are modulated in pancreatic diseases and could contribute differently to tumour development.

PMID: 19585519 [PubMed - indexed for MEDLINE]

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.

Fetched: November 27th, 2009, 11:17am CST

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.

Int J Clin Exp Pathol. 2009;3(1):47-55

Authors: Karafin MS, Cummings CT, Fu B, Iacobuzio-Donahue CA

GATA4 is a transcription factor that plays a role in regulating the normal development of many mesoderm and endoderm derived tissues, including the pancreas. Silencing of GATA4 mRNA expression by promoter methylation has been implicated in carcinogenesis of the ovary, lung and colorectum. By contrast, GATA4 mRNA expression is upregulated in pancreatic cancer cell lines and tissues. To further clarify the relationship of GATA4 to pancreatic cancer, we immunolabeled 90 samples of pancreatic ductal adenocarcinoma using a GATA4 specific monoclonal antibody. Both the intensity and percent of labeling was recorded for each carcinoma and correlated to the clinic opathologic features available for each patient. Samples of normal adult (n=26) and fetal pancreatic tissue (n=8) were also immunolabeled for comparison to expression patterns in pancreatic carcinoma tissues. Immunolabeling for GATA4 indicated robust nuclear expression in developing acini in fetal pancreatic tissues, consistent with the role of GATA4 in embryologic development, and in mature pancreatic acinar epithelium. Immunolabeling for GATA4 was also noted within normal duct epithelial cells, although it was always lesser in intensity than for acinar cell nuclei in the same section. Positive GATA4 immunolabeling was seen in 61/90 (68%) infiltrating pancreatic cancers of which 27/90 (30%) showed strong positive labeling. While there was no relationship among GATA4 and patient age, race or pathologic features, we did find a significant association among strong positive labeling and female gender (p=0.01). These findings support previous studies implicating GATA4 in pancreatic cancer and offer new avenues for investigation into this aggressive tumor type.

PMID: 19918328 [PubMed - in process]

$Permalink for 'Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.'$

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.

Fetched: November 27th, 2009, 11:17am CST

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.

Cancer Sci. 2009 Oct 22;

Authors: Tanaka H, Fukamachi K, Futakuchi M, Alexander DB, Long N, Tamamushi S, Minami K, Seino S, Ohara H, Joh T, Tsuda H

Pancreatic ductal adenocarcinoma (PDA) is one of the most debilitating malignancies in humans. A thorough understanding of the cytogenesis of this disease will aid in establishing successful treatments. We have developed an animal model which uses adult Hras(G12V) and Kras(G12V) transgenic rats in which oncogene expression is regulated by the Cre/loxP system and neoplastic lesions are induced by injection of adenovirus-expressing Cre recombinase. When adenovirus with Cre recombinase under the control of the CMV enhancer/chicken beta-actin (CAG) promoter (Ad-CAG-Cre) is injected into the pancreatic duct of these animals, pancreatic neoplasias develop. Pathologically, the origin of these lesions is duct, intercalated duct, and centroacinar cells, but not acinar cells. The present study was undertaken to test the effect of acinar cell-specific oncogenic ras expression. Adult transgenic rats were injected with adenovirus with Cre recombinase under the control of the acinar cell-specific promoters amylase (Ad-Amy-Cre) and elastase-1 (Ad-Ela-Cre) or under the control of the non-specific CAG promoter. Injection of either Ad-Amy-Cre or Ad-Ela-Cre into the pancreatic ducts of transgenic animals in which oncogenic Kras is tagged with hemagglutinin (HA), HA-Kras(G12V) rats resulted in expression of oncogenic ras in acinar cells but not in duct, intercalated duct, or centroacinar cells. Notably, injected animals did not develop any observable proliferative or neoplastic lesions. In marked contrast, injection of Ad-CAG-Cre resulted in pancreatic cancer development within 4 weeks. These results indicate that adult acinar cells are refractory to Ras oncogene activation and do not develop neoplasia in this model. (Cancer Sci2009).

PMID: 19917056 [PubMed - as supplied by publisher]

Microadenocarcinoma of the pancreas.

Fetched: November 27th, 2009, 11:17am CST

Microadenocarcinoma of the pancreas.

Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1373-8

Authors: Chen Y, Yu G, Ma D, Ni C, Zhu M

BACKGROUND: Microadenocarcinoma (MA) of the pancreas is a rare kind of neoplasm, whose status as an independent tumor entity is still a matter of controversy. METHODS AND RESULTS: In this article we investigated two patients with MA from the histological, immunohistochemical and genetic aspects. Morphologically, MA is composed of small, crowded microglandular structures, forming a cribriform pattern, sometimes solid sheets. Cells of MA were morphologically uniform and were less pleomorphic than those of the ductal adenocarcinoma. Immunohistochemistry revealed that MA, though with a certain extent of epithelial differentiation, possesses a different immunological phenotype from those of ductal carcinoma, acinar cell carcinoma, and endocrine tumors. Genetic analysis showed no abnormality of p53, K-ras, and beta-catenin, which were usually mutated in pancreatic ductal adenocarcinoma. CONCLUSION: Therefore, we suggest that MA should be taken as an independent tumor entity rather than a kind of growth pattern, but a final decision should be reached after cautious differential diagnosis of other kinds of pancreatic neoplasms.

PMID: 19916245 [PubMed - in process]

Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.

Fetched: November 27th, 2009, 11:17am CST

Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.

Virchows Arch. 2009 Nov 12;

Authors: Chiaravalli AM, Finzi G, Bertolini V, La Rosa S, Capella C

A case of a colonic carcinoma showing a pancreatic acinar cell differentiation is described for the first time. A 65-year-old woman underwent surgical resection for an ulcerated protruding tumour of 4 x 2.5 cm in size on the anterior wall of the sigmoid colon. Histologically, tumour cells were organized in acinar structures resembling pancreatic acini and in solid nests and ribbons or diffusely infiltrated as poorly cohesive cells. Lymph nodes and femur metastases displayed the same histological features. The ultrastructural analysis of the primary tumour indicated the presence of zymogen-like granules in the cytoplasm of tumour cells. Immunohistochemically, both acinar and diffuse patterns of growth showed an intense staining for trypsin, chymotrypsin and BCL10 and a weaker immunoreactivity for lipase and carboxyl ester hydrolase. Most tumour cells were cytokeratin 20, CDX2 and p53 positive; whereas, mucin (MUC)2 immunoreactivity was observed only in the signet ring cells present in the diffuse pattern and chromogranin A in rare isolated tumour cells. No immunoreactivity was observed for cytokeratin 7, MUC1, MUC5AC, pancreatic amylase or PDX1. There was no evidence of a pancreatic acinar cell carcinoma or of heterotopic pancreatic tissue. A colonic origin ought to be suspected when a metastatic carcinoma of unknown primary shows an acinar differentiation.

PMID: 19908063 [PubMed - as supplied by publisher]

Spontaneous rupture of the splenic metastasis in acinar cell carcinoma.

Fetched: November 27th, 2009, 11:17am CST

Spontaneous rupture of the splenic metastasis in acinar cell carcinoma.

Pancreas. 2009 Oct;38(7):836-8

Authors: Ando K, Ohkuni Y, Kaneko N, Narita M

PMID: 19893460 [PubMed - in process]

Acinar cell carcinoma of the pancreas with intraductal growth: report of a case.

Fetched: November 27th, 2009, 11:17am CST

Acinar cell carcinoma of the pancreas with intraductal growth: report of a case.

Surg Today. 2009;39(11):1006-9

Authors: Imamura M, Kimura Y, Ito H, Nobuoka T, Koito K, Sasaki A, Hirata K

Acinar cell carcinomas (ACCs) of the pancreas are rare neoplasms, accounting for approximately 1% of all exocrine pancreatic tumors. This type of tumor is known to be aggressive, although the survival rates are somewhat better than they are for ductal carcinoma. The tumor tends to present nonspecific symptoms. It occurs in older patients, and jaundice is infrequent. This report presents a case of ACC of the pancreas with intraductal papillary growth and lymph node metastasis.

PMID: 19882327 [PubMed - in process]

Fine-needle aspiration of dedifferentiated acinic cell carcinoma: Report of a case with cyto-histological correlation.

Fetched: November 27th, 2009, 11:17am CST

Fine-needle aspiration of dedifferentiated acinic cell carcinoma: Report of a case with cyto-histological correlation.

Diagn Cytopathol. 2009 Oct;37(10):763-8

Authors: Johnykutty S, Miller CH, Hoda RS, Giampoli EJ

Dedifferentiated Acinic Cell Carcinoma (DAcCC) is a rare salivary gland malignancy. It has a high tendency to recur and metastasize and thus has a poor prognosis. So far, to our knowledge, only one case of DAcCC has been reported in the cytology literature. Herein, we describe a second case of DAcCC from a fine-needle aspiration (FNA) along with its subsequent histological correlation.

PMID: 19526576 [PubMed - indexed for MEDLINE]

Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst.

Fetched: January 31st, 2010, 3:49pm CST

Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst.

Indian J Pathol Microbiol. 2010 Jan-Mar;53(1):190-2

Authors: Jena M, Shariff S, Jeyachandran P

PMID: 20090274 [PubMed - in process]

[A case of acinar cell carcinoma of pancreas with liver metastases treated effectively by s-1.]

Fetched: January 21st, 2010, 6:02pm CST

[A case of acinar cell carcinoma of pancreas with liver metastases treated effectively by s-1.]

Gan To Kagaku Ryoho. 2010 Jan;37(1):127-9

Authors: Morishima K, Hyodo M, Nihei Y, Sata N, Yasuda Y

PMID: 20087046 [PubMed - in process]

Promotion of beta-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells.

Fetched: January 20th, 2010, 9:02am CST

Promotion of beta-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells.

Biomed Pharmacother. 2010 Jan 4;

Authors: Kawakami M, Hirayama A, Tsuchiya K, Ohgawara H, Nakamura M, Umezawa K

PMID: 20079600 [PubMed - as supplied by publisher]

Mixed adenocarcinomas of the lung: place in new proposals in classification, mandatory for target therapy.

Fetched: January 20th, 2010, 9:02am CST

Mixed adenocarcinomas of the lung: place in new proposals in classification, mandatory for target therapy.

Arch Pathol Lab Med. 2010 Jan;134(1):55-65

Authors: Chilosi M, Murer B

PMID: 20073606 [PubMed - in process]

Acinic cell carcinoma of the salivary glands: a literature review.

Fetched: January 20th, 2010, 9:02am CST

Acinic cell carcinoma of the salivary glands: a literature review.

Hematol Oncol Stem Cell Ther. 2009;2(1):259-64

Authors: Al-Zaher N, Obeid A, Al-Salam S, Al-Kayyali BS

Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men. Previous radiation exposure and familial predisposition are some of the risk factors for ACC. A slowly enlarging mass lesion in the tail of the parotid gland is the most frequent presentation. The diagnosis is usually confirmed with a fine needle aspiration biopsy, and surgical excision is the main treatment of this malignant neoplasm. Other treatment modalities such as radiotherapy may be indicated in some cases. ACC has a significant tendency to recur, to produce metastases (cervical lymph nodes and lungs), and may have an aggressive evolution. Therefore, long-term follow-up is mandatory after treatment.

PMID: 20063555 [PubMed - in process]

Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.

Fetched: January 20th, 2010, 9:02am CST

Serine protease inhibitor Kazal type 1 promotes proliferation of pancreatic cancer cells through the epidermal growth factor receptor.

Mol Cancer Res. 2009 Sep;7(9):1572-81

Authors: Ozaki N, Ohmuraya M, Hirota M, Ida S, Wang J, Takamori H, Higashiyama S, Baba H, Yamamura K

PMID: 19737965 [PubMed - indexed for MEDLINE]

Parotidotomy approach for a midcheek mass: A new surgical strategy.

Fetched: January 10th, 2010, 2:29pm CST

Parotidotomy approach for a midcheek mass: A new surgical strategy.

Laryngoscope. 2010 Jan 7;

Authors: Jung YH, Hah JH, Sung MW, Kim KH

OBJECTIVES/HYPOTHESIS:: To report the feasibility and the results of a new surgical strategy for midcheek masses we called the parotidotomy approach. STUDY DESIGN:: Retrospective consecutive case series. METHODS:: Characteristics, surgical outcome, and cosmetic result of cases managed using the parotidotomy approach were collected by retrospectively reviewing medical records. The standard superficial parotidectomy approach was modified to dissect facial nerve branches selectively to obtain a symmetric facial contour. The parotid gland was fully bisected along the course of the zygomatic and buccal branches of the facial nerve to provide access to the midcheek mass. The bisected parotid gland was repositioned after mass excision. RESULTS:: Seven patients (3 males and 4 females) were included in this study. The parotidotomy approach was accomplished in two cases with a malignant tumor (one acinic cell carcinoma, one low-grade mucoepidermoid carcinoma), four with a benign tumor (two pleomorphic adenoma, one basal cell adenoma, one facial nerve schwannoma), and in one case with a chronic inflammatory lesion (chronic sialadenitis). In no case was facial nerve paralysis or Frey's syndrome noticed after this approach. For the two malignant tumors, there was no evidence of recurrence or metastasis at 2-year and 2.5-year follow-ups. Six of the seven patients were fully satisfied with the cosmetic results of surgery. The remaining patient had a mild sunken deformity of the midcheek where the mass had been located. CONCLUSIONS:: To manage midcheek masses we modified the standard parotidectomy approach. This new surgical strategy, which we named the parotidotomy approach, provides surgically safe and cosmetically excellent results for midcheek masses. Laryngoscope, 2010.

PMID: 20058313 [PubMed - as supplied by publisher]

Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children's Hospital.

Fetched: January 10th, 2010, 2:29pm CST

Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children's Hospital.

Pediatr Dev Pathol. 2010 Jan 7;

Authors: Craver RD, Fonseca P, Carr R

Abstract There are conflicting reports regarding the relative frequency of benign and malignant epithelial salivary gland tumors in children. There are only a few reports of the cytogenetic abnormalities in the pleomorphic adenomas (PA) that arise in children, and even less information regarding the pleomorphic adenoma gene 1 (PLAG1) and high motility group A2 (HMGA2 ) histochemical staining in PAs, or their correlation with histologic types (stromal vs epithelial predominance). A retrospective 14 year review of epithelial salivary gland tumors encountered at a children's hospital identified 13 tumors- 12 PAs and 1 acinic cell carcinoma (ACC). No mucoepidermoid carcinomas were identified. Tumors arose in the parotid (7) and other sites (2 submandibular, 4 minor). Ten PAs in our cohort had cytogenetic studies. Four were normal, 5 involved 8q12, and 1 involved 12q13. Immunohistochemistry identified an additional 2 PAs with PLAG1 staining, and 5 additional PAs with HMGA2 staining. One tumor with ins(18;8)(q21.1;q12q22.2) had no PLAG1 staining, but stained with HMGA2. This ins(18;8) may not have involved the PLAG1 gene. There was no demonstrable corrrelation of 8q12/PLAG1 staining or 12q13/HMGA2 staining with histologic type. Thus we found abnormalities in either 8q12/PLAG1 staining or 12q13/HMGA2 staining in all PAs. The HMGA2 staining in 50% of PAs suggests that it may more frequently involved in PAs than previously thought based on cytogenetic studies, at least in children.Key Words: childhood, high motility group protein, pleomorphic adenoma, pleomorphic adenoma gene 1, salivary gland neoplasm.

PMID: 20055685 [PubMed - as supplied by publisher]

Pancreatic-type mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from the stomach: a report of an extremely rare case.

Fetched: January 10th, 2010, 2:29pm CST

Pancreatic-type mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from the stomach: a report of an extremely rare case.

Med Mol Morphol. 2009 Sep;42(3):167-74

Authors: Kusafuka K, Bando E, Muramatsu K, Ito H, Tanizawa Y, Kawamura T, Mochizuki T, Terashima M, Nakajima T

PMID: 19784744 [PubMed - indexed for MEDLINE]

A prognostic index for predicting lymph node metastasis in minor salivary gland cancer.

Fetched: January 10th, 2010, 2:29pm CST

A prognostic index for predicting lymph node metastasis in minor salivary gland cancer.

Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):169-75

Authors: Lloyd S, Yu JB, Ross DA, Wilson LD, Decker RH

PMID: 19386433 [PubMed - indexed for MEDLINE]

[CT features of parotid tumors: an analysis of 133 cases]

Fetched: December 27th, 2009, 9:49am CST

[CT features of parotid tumors: an analysis of 133 cases]

Ai Zheng. 2007 Nov;26(11):1263-7

Authors: Lu YC, Fan WJ, Shen JX, Xiao P

PMID: 17991330 [PubMed - indexed for MEDLINE]

An Update of the Gleason Grading System.

Fetched: December 22nd, 2009, 8:01am CST

An Update of the Gleason Grading System.

J Urol. 2009 Dec 12;

Authors: Epstein JI

PMID: 20006878 [PubMed - as supplied by publisher]

Pancreatic tumors in children and adolescents: The Italian TREP project experience.

Fetched: December 22nd, 2009, 8:01am CST

Pancreatic tumors in children and adolescents: The Italian TREP project experience.

Pediatr Blood Cancer. 2009 Dec 8;

Authors: Dall'igna P, Cecchetto G, Bisogno G, Conte M, Chiesa PL, D'Angelo P, De Leonardis F, De Salvo G, Favini F, Ferrari A,

PMID: 19998473 [PubMed - as supplied by publisher]

[Case of pulmonary adenocarcinoma with co-existing pulmonary actinomycosis in one region of the lung]

Fetched: December 22nd, 2009, 8:01am CST

[Case of pulmonary adenocarcinoma with co-existing pulmonary actinomycosis in one region of the lung]

Nihon Kokyuki Gakkai Zasshi. 2009 Sep;47(9):823-7

Authors: Ide S, Sawai T, Kaku N, Nagayoshi Y, Soda H, Kohno S

PMID: 19827588 [PubMed - indexed for MEDLINE]

Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.

Fetched: December 22nd, 2009, 8:01am CST

Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.

Am J Surg Pathol. 2009 Dec;33(12):1752-64

Authors: Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD

PMID: 19773638 [PubMed - indexed for MEDLINE]

Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells.

Fetched: December 22nd, 2009, 8:01am CST

Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells.

Int J Oncol. 2009 Oct;35(4):823-8

Authors: Pan Z, Erkan M, Streit S, Friess H, Kleeff J

PMID: 19724918 [PubMed - indexed for MEDLINE]

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

Fetched: December 22nd, 2009, 8:01am CST

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

J Pathol. 2009 Oct;219(2):205-13

Authors: Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I

PMID: 19585519 [PubMed - indexed for MEDLINE]

A Slow-Growing Palatal Mass: A Challenging Differential Diagnosis.

Fetched: December 9th, 2009, 7:36am CST

A Slow-Growing Palatal Mass: A Challenging Differential Diagnosis.

J Oral Maxillofac Surg. 2009 Dec 1;

Authors: Marques KD, Andrade FR, Castro LA, Vêncio EF, Mendonça EF, Ribeiro-Rotta RF, Silva TA, Batista AC

PURPOSE: The purpose of this article is to present an additional case of clear cell carcinoma, not otherwise specified (CCC-NOS) and to review in detail the microscopic differential diagnosis of clear cell neoplasms, which encompasses a broad range of possibilities. PATIENT AND METHODS: A 41-year-old man presented with a slow-growing palatal mass. Intraoral examination revealed a submucosal mass on the right side of the hard palate. Conventional radiographs, computed tomography (CT) and magnetic resonance (MR) imaging were analyzed. A microscopic examination of an incisional biopsy specimen was performed. Histochemical and immunohistochemical studies were carried out in order to establish the microscopic differential diagnosis. RESULTS: Conventional radiographs showed an osteolytic lesion in the premolar area as well as tooth resorption in the right second molar. CT and MR imaging showed a neoplasm extending from the premolars to the tuberosity region on the right side of the maxilla and the resorption of the ipsilateral maxillary sinus floor. The microscopic examination revealed a monomorphous population of polygonal and round cells with abundant and clear cytoplasm, arranged in nests and cords. Clear cells were negative for mucicarmine and periodic acid-Schiff. The immunohistochemical study showed that the neoplastic clear cells were positive for cytokeratin 8 and 7, but negative for S100, vimentin, and smooth muscle actin. On jointly considering the microscopic, histochemical, and immunohistochemical features, the diagnosis of CCC-NOS was established. Using differential diagnosis as a basis, epithelial myoepithelial carcinoma, myoepithelial carcinoma, mucoepidermoid carcinoma, acinic cell carcinoma, oncocytoma (clear cell variant), malignant sebaceous tumors, and metastasis from renal carcinoma were all ruled out. The patient underwent hemimaxillarectomy and adjuvant radiotherapy. CONCLUSION: Determining CCC-NOS and distinguishing this tumor from other clear cell neoplasms is crucial to establishing the appropriate diagnosis and therapeutic approach.

PMID: 19954872 [PubMed - as supplied by publisher]

Matrix metalloproteinase (MMP)-7 in salivary gland cancer.

Fetched: November 27th, 2009, 11:17am CST

Matrix metalloproteinase (MMP)-7 in salivary gland cancer.

Acta Oncol. 2009 Nov 24;

Authors: Luukkaa H, Klemi P, Hirsimäki P, Vahlberg T, Kivisaari A, Kähäri VM, Grénman R

Abstract Introduction. High levels of certain matrix metalloproteinases (MMPs) have been detected in various human cancers. The purpose of this study was to analyze the expression of MMP-7 in salivary gland cancer (SGC) by immunohistochemistry and to associate the results with the clinical data and the 10-year survival of the SGC patients. Material and methods. Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC. The samples represent the entire SGC population in Finland from 1991-1996. Mortality follow-up ended December 31, 2006. Results. The study population of 107 patients consisted of 47 male and 60 female subjects, ranging in age at the time of diagnosis between 23 and 90 years. The minimum follow-up time was 10.6 years and the maximum 15.9 years. By age-adjusted analysis lower staining intensity was associated with worse overall survival of patients with acinic cell carcinoma (p = 0.047, HR 6.5, 95% Cl 1.0-41.7) and in mucoepidermoid carcinoma (p = 0.010, HR 9.3, 95% CI 1.7-50.0). Low staining intensity was also associated with worse disease-specific survival of patients with acinic cell carcinoma (0-1 vs. 2-3; p = 0.047, HR 13.7, 1.0-200.0). VCI Ki-67 was an important prognostic factor for survival of the entire data set (p < 0.0001, HR 4.7, 95% Cl 2.3-9.8). Conclusions. MMP-7 is associated with the prognosis of patients with acinic cell and mucoepidermoid carcinoma.

PMID: 19929564 [PubMed - as supplied by publisher]

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review.

Fetched: November 27th, 2009, 11:17am CST

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review.

Diagn Cytopathol. 2009 Nov 19;

Authors: Kawahara A, Harada H, Mihashi H, Akiba J, Kage M

Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors. Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis between benign lesions and malignant tumors with cystic growth. We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 x 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these findings on FNAC. Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue. The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells. There was neither a definite double-layered arrangement in cystic ducts and solid islands nor histological findings characteristic of the papillary-cystic or follicular pattern of ACC-PCV. As tumor cells with a small vacuolated, soap-bubble appearance of the cytoplasm are common findings of both cystadenocarcinoma and ACC-PCV, they are of little use for differentiation; however, they are so characteristic that the majority of benign salivary gland lesions with cystic structures can be excluded, if enough attention is paid. Diagn. Cytopathol. 2010. (c) 2009 Wiley-Liss, Inc.

PMID: 19927358 [PubMed - as supplied by publisher]

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.

Fetched: November 27th, 2009, 11:17am CST

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.

Int J Clin Exp Pathol. 2009;3(1):47-55

Authors: Karafin MS, Cummings CT, Fu B, Iacobuzio-Donahue CA

PMID: 19918328 [PubMed - in process]

$Permalink for 'Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.'$

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.

Fetched: November 27th, 2009, 11:17am CST

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats.

Cancer Sci. 2009 Oct 22;

Authors: Tanaka H, Fukamachi K, Futakuchi M, Alexander DB, Long N, Tamamushi S, Minami K, Seino S, Ohara H, Joh T, Tsuda H

PMID: 19917056 [PubMed - as supplied by publisher]

Microadenocarcinoma of the pancreas.

Fetched: November 27th, 2009, 11:17am CST

Microadenocarcinoma of the pancreas.

Eur J Gastroenterol Hepatol. 2009 Dec;21(12):1373-8

Authors: Chen Y, Yu G, Ma D, Ni C, Zhu M

PMID: 19916245 [PubMed - in process]

Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.

Fetched: November 27th, 2009, 11:17am CST

Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.

Virchows Arch. 2009 Nov 12;

Authors: Chiaravalli AM, Finzi G, Bertolini V, La Rosa S, Capella C

PMID: 19908063 [PubMed - as supplied by publisher]

Spontaneous rupture of the splenic metastasis in acinar cell carcinoma.

Fetched: November 27th, 2009, 11:17am CST

Spontaneous rupture of the splenic metastasis in acinar cell carcinoma.

Pancreas. 2009 Oct;38(7):836-8

Authors: Ando K, Ohkuni Y, Kaneko N, Narita M

PMID: 19893460 [PubMed - in process]

Acinar cell carcinoma of the pancreas with intraductal growth: report of a case.

Fetched: November 27th, 2009, 11:17am CST

Acinar cell carcinoma of the pancreas with intraductal growth: report of a case.

Surg Today. 2009;39(11):1006-9

Authors: Imamura M, Kimura Y, Ito H, Nobuoka T, Koito K, Sasaki A, Hirata K

PMID: 19882327 [PubMed - in process]

Battle of a lifetime: Poole says don't give up after cancer diagnosis - Bluefield Daily Telegraph

Posted: January 25th, 2010, 2:12am CST

Battle of a lifetime: Poole says don't give up after cancer diagnosis
Bluefield Daily Telegraph
Since that time, the cancer — adenoid cystic carcinoma or ACE for short — has injured her face and claimed her ability to speak. Despite this, Poole keeps ...

Kalispell Medical Marijuana Clinic Draws Huge Crowd - New West

Posted: January 24th, 2010, 9:21am CST

New West

Kalispell Medical Marijuana Clinic Draws Huge Crowd
New West
Leduc, who came to the clinic from Lake County, was diagnosed with adenoid cystic carcinoma last year and said she did not want to take traditional pain ...

and more »

Kalispell Medical Marijuana Clinic Draws Huge Crowd - Flathead Beacon

Posted: January 22nd, 2010, 8:20pm CST

Flathead Beacon

Kalispell Medical Marijuana Clinic Draws Huge Crowd
Flathead Beacon
Leduc, who came to the clinic from Lake County, was diagnosed with adenoid cystic carcinoma last year and said she did not want to take traditional pain ...

Good Morning: South - Pittsburgh Post Gazette

Posted: January 21st, 2010, 3:50am CST

Good Morning: South
Pittsburgh Post Gazette
His mother, Julie, has been fighting her own battle with metastatic adenoid cystic carcinoma and has endured multiple surgeries and radiation treatments. ...

Pathology Quiz Case 1: Diagnosis - Archives of Otolaryngology

Posted: January 18th, 2010, 1:24pm CST

Pathology Quiz Case 1: Diagnosis
Archives of Otolaryngology
Adenoid cystic carcinoma is differentiated by the presence of irregular nuclei, high mitotic rates, frequent central necrosis, and pseudocysts containing ...

HCG set to become a key hub for cancer care in India's medical tourism chart ... - pharmabiz.com

Posted: January 12th, 2010, 9:46pm CST

HCG set to become a key hub for cancer care in India's medical tourism chart ...
pharmabiz.com
The hospital has now successfully treated a patient from Holland who was diagnosed of Stage IV adenoid cystic carcinoma commonly referred to as head and ...

'Tricia's Tree' raises money for cancer research - Southtown Star

Posted: December 25th, 2009, 2:09am CST

'Tricia's Tree' raises money for cancer research
Southtown Star
Mason died in early August at age 35 after a yearlong battle with adenoid cystic carcinoma, a rare cancer of the salivary glands. ...

Basaloid squamous cell carcinoma: two case reports - 7thSpace Interactive (press release)

Posted: December 18th, 2009, 9:11am CST

Basaloid squamous cell carcinoma: two case reports
7thSpace Interactive (press release)
BSCC of the head and neck should be distinguished from adenoid cystic carcinoma, small cell neuroendocrine carcinoma, basal cell adenocarcinoma, ...

Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period.

Fetched: January 31st, 2010, 3:49pm CST

Tumours of the submandibular salivary gland: a clinicopathologic review of cases over a 17-year period.

West Indian Med J. 2009 Sep;58(4):388-91

Authors: Adeyemo WL, Ajayi OF, Anunobi CC, Ogunlewe MO, Ladeinde AL, Omitola OG, Abdulkareem FB

OBJECTIVE: This study presents a clinicopathologic review of cases of submandibular salivary gland tumours at the Lagos University Teaching Hospital, Nigeria, over a period of 17 years. METHODS: The records of all patients with histological diagnosis of submandibular salivary gland tumours at the Lagos University Teaching Hospital over a period of 17 years (January 1990 to December 2006) were retrospectively reviewed. Parameters studied were; age and gender of patients, symptoms and duration of symptoms, and histological diagnosis. RESULTS: A total of 36 patients with submandibular gland tumours were seen during the period. Male-to-female ratio was 1.8:1 (male=23, female=13). Mean age (+/- SD) at presentation was 43 (+/- 19) years (age range, 17-84 years). There were 19 malignant tumours and 17 benign ones. Pleomorphic adenoma (36.1%) was the most frequent tumours, followed by adenoid cystic carcinoma (11.1%), anaplastic carcinoma (11.1%) and malignant lymphoma (11.1%). Patients with histological diagnosis of malignant tumours were significantly older than those with benign tumours (p = 0.01). Most patients (80.6%) presented with painless swelling. CONCLUSION: Malignant submandibular salivary gland tumours were slightly more than the benign ones in the studied population. Painful swelling or ulceration is indicative of a malignant submandibular gland tumour

PMID: 20099784 [PubMed - in process]

Adenoid cystic carcinoma of the Bartholin's gland in a young patient: eight-year follow-up.

Fetched: January 31st, 2010, 3:49pm CST

Adenoid cystic carcinoma of the Bartholin's gland in a young patient: eight-year follow-up.

Eur J Gynaecol Oncol. 2009;30(6):686-8

Authors: Korkontzelos I, Fragkoulidis M, Stavroulis A, Apostolikas N, Terzakis E

Adenoid cystic carcinoma (ACC) of the Bartholin's gland is one of the rarest neoplasms of the female genital tract. Including this report there are 65 cases mentioned in the literature. We report a case of a 36-year-old woman who presented at our hospital after excision of the right Bartholin gland elsewhere which proved to be ACC. The therapy of this rare tumor has many controversial questions and dilemmas, especially in young patients. Our patient underwent surgical treatment only (hemivulvectomy and lymph node dissection) without radiotherapy and is free of disease eight years after.

PMID: 20099506 [PubMed - in process]

Sinonasal adenoid cystic carcinoma presenting as an orbital mass.

Fetched: January 31st, 2010, 3:49pm CST

Sinonasal adenoid cystic carcinoma presenting as an orbital mass.

Ophthal Plast Reconstr Surg. 2010 Jan-Feb;26(1):54-6

Authors: Kwon RO, Lyon DB, Floyd M, Girod DA

A 61-year-old man with a history of sinus polyposis and prior sinus surgery presented with left-sided retrobulbar pain and headache. He was found to have left-sided proptosis, and imaging studies showed a large left medial orbital soft-tissue mass. Incisional biopsy revealed adenoid cystic carcinoma. Further evaluation revealed extensive sinonasal adenoid cystic carcinoma. The patient underwent en bloc maxillectomy with orbital exenteration and partial rhinectomy, followed by radiation therapy. The medial orbit is an unusual location for adenoid cystic carcinoma, which the authors believe was a secondary manifestation due to perineural spread from the sinuses via the ethmoidal nerves. Adenoid cystic carcinoma should be included in the differential diagnosis of tumors of the medial orbit, especially if there is a history of sinonasal disease.

PMID: 20090492 [PubMed - in process]

Social challenges of cancer patients with orbitofacial disfigurement.

Fetched: January 31st, 2010, 3:49pm CST

Social challenges of cancer patients with orbitofacial disfigurement.

Ophthal Plast Reconstr Surg. 2010 Jan-Feb;26(1):18-22

Authors: Bonanno A, Esmaeli B, Fingeret MC, Nelson DV, Weber RS

PURPOSE: Patients who undergo orbital exenteration often experience social problems because of their facial disfigurement. The authors studied the interaction of cancer patients who had undergone orbital exenteration with family members and friends (primary groups) and with acquaintances and strangers (secondary groups) in small and large groups. METHODS: In-depth telephone interviews were conducted with 12 patients treated at a cancer center (7 men and 5 women aged 51-81 years) and 12 family members (8 spouses and 4 children or siblings). Three patients had adenoid cystic carcinoma of lacrimal gland, 3 had squamous cell carcinoma of conjunctiva/eyelid, and 1 each had conjunctival melanoma, eyelid sebaceous gland carcinoma, transitional cell carcinoma of lacrimal sac, adenocarcinoma of orbit, neuroendocrine carcinoma of orbit, and basal cell carcinoma of eyelid. Time from orbital exenteration to interview ranged from 8 months to 36 years (median, 44 months). RESULTS: Two patient groups were identified according to comfort in interactions with acquaintances and strangers. Always comfortable patients were always at ease. Occasionally comfortable patients were at ease in large groups in situations of "benign neglect" and in small groups when they received "sympathy"; were uncomfortable in large and small groups when episodes of "intrusion" occurred; and had mixed responses to benign neglect in small groups and sympathy in large groups. Both patient groups felt comfortable with family members and friends. CONCLUSIONS: Patients who will undergo orbital exenteration should be warned about possible difficulties with social interactions. Healthcare personnel should be trained to help patients and family members prepare for such difficulties.

PMID: 20090478 [PubMed - in process]

Population Based Cancer Registry Analysis of Primary Tracheal Carcinoma.

Fetched: January 21st, 2010, 6:02pm CST

Population Based Cancer Registry Analysis of Primary Tracheal Carcinoma.

Am J Clin Oncol. 2010 Jan 15;

Authors: Urdaneta AI, Yu JB, Wilson LD

INTRODUCTION:: Primary carcinomas of the trachea are rare tumors, occurring at a rate of 2.6 new cases per 1,000,000 people per year. This study investigates the large observational cohort of patients recorded in the NCI Surveillance, Epidemiology, and End Results (SEER) 1973-2004 database, and provides information regarding epidemiology, treatment, and prognosis. METHODS:: The SEER database was investigated, and all patients for whom primary tracheal carcinoma was the first and only cancer were investigated. Demographic information was investigated. The cohort was analyzed for variables effecting survival, including age, gender, race, histology, extent of disease, extent of surgery, use of radiation, and year of diagnosis. RESULTS:: Between 1973 and 2004, 578 cases of primary tracheal carcinomas were reported in the SEER database. There were 322 men (55.7%) and 256 women (44.3%). Squamous cell carcinoma was the predominant histology, representing 259 tumors (44.8%). Adenoid cystic carcinoma (ACC) was the second most common tumor (16.3%). Localized, regional and distant disease was found in 140 (24.2%), 212 (36.7%), and 108 (18.7%), respectively. Twenty percent of the patients did not undergo staging. Patients with localized disease had a better prognosis than those with regional (P = 0.001) or distant disease (P = <0.001).A significant fraction of patients did not receive cancer directed local therapy; 34.3% did not undergo surgery and 29.1% did not receive any kind of radiation therapy. There was a statistically significant improved survival for patients who underwent any type of surgery in comparison with patients who did not undergo cancer directed surgery. There was no statistical benefit for patients who underwent radiation therapy.General overall 5-year survival for all patients was 27.1% (95% CI: 23.1-33.3%). Patients with localized disease had a better outcome than patients with regional or distant disease with an overall 5-year survival of 46% (95% CI: 37.3%-55.8%). Squamous cell carcinoma tumors had worse outcomes than any other histologic type, with a 5 year overall survival of 12.6% (95% CI: 8.4-17.6%). In contrast, 5-year overall survival for AACs was relatively good at 74.3% (95% CI: 63.1-82.5). For localized disease, 5-year survival was 24.7% (95% CI: 12.8-38.7%) for squamous cell carcinoma versus 90.5% (95% CI: 73.3-96.8%) for ACCs (P < 0.001). CONCLUSION:: Primary tracheal tumors are very uncommon; squamous cell carcinoma is the most common histologic type, followed by ACCs. General 5-year overall survival is poor, though localized disease has better survival when compared with regional or distant disease. There is a remarkable difference in survival between squamous cell carcinoma and ACC.

PMID: 20087156 [PubMed - as supplied by publisher]

[Clinical characteristics of 8 cases of primary tracheal tumors.]

Fetched: January 20th, 2010, 9:02am CST

[Clinical characteristics of 8 cases of primary tracheal tumors.]

Zhonghua Jie He He Hu Xi Za Zhi. 2009 Sep;32(9):660-3

Authors: Wen SL, Zhou X, Hu HH, Peng ZZ

OBJECTIVE: To explore the clinical characteristics of primary tracheal tumors and therefore to improve the diagnosis and treatment. METHODS: A retrospective analysis of the clinical data of 8 patients with primary tracheal tumors admitted to our department during the period of May 1994 to May 2006 was performed, with detailed description of the clinical manifestations, chest radiography, fiberoptic bronchoscopy, lung function measurements, treatment and prognosis for 4 cases. RESULTS: Seven patients presented with irritable cough and progressive inspiratory dyspnea, mostly misdiagnosed as asthma or chronic bronchitis. Examination by fiberoptic bronchoscopy confirmed the diagnosis of tracheal tumor in all the cases. One case with benign neurinoma and 2 cases with adenoid cystic carcinomas had a long-term postoperative remission. Two cases of squamous cell carcinoma with severe tracheal stenosis got rapid symptom remission after intervention of tracheal stent by fiberoptic bronchoscopy and argon plasma coagulation. One patient with adenoid cystic carcinoma refused any treatment. One patient with squamous cell carcinoma lost follow-up after surgery. One patient with adenocarcinoma died of progressive deterioration after 2 month chemotherapy. CONCLUSIONS: Primary tracheal tumors occur infrequently and early clinical symptoms are unspecific. Early diagnosis can be made by chest CT and fiberoptic bronchoscopy. Benign tracheal tumors can be resected, and for some low-grade malignant tumors surgical resection and postoperative radiotherapy can improve long term survival. Intervention with fiberoptic bronchoscopy to unresectable diseases can lead to symptom remission and thus improve patient's life quality.

PMID: 20079278 [PubMed - in process]

Parenchyma-sparing bronchial sleeve resections in trauma, benign and malign diseases.

Fetched: January 20th, 2010, 9:02am CST

Parenchyma-sparing bronchial sleeve resections in trauma, benign and malign diseases.

Thorac Cardiovasc Surg. 2010 Feb;58(1):32-7

Authors: Bölükbas S, Schirren J

OBJECTIVE: We evaluated our experience with parenchyma-sparing bronchial sleeve resections in trauma, benign and malign disease to determine the operative morbidity, mortality and long-term outcome. METHODS: We retrospectively reviewed our prospective database of all patients who underwent bronchial sleeve resection without parenchymal loss. Clinical data, morbidity, mortality and survival were analyzed. RESULTS: From January 1999 through December 2008, 19 patients (11 male) underwent bronchial sleeve resection without removal of pulmonary parenchyma. Median age was 42.2 +/- 12.2 years (range 18 to 70 years). Indications were carcinoid tumors (n = 14), adenoid cystic carcinoma (n = 1), non-small cell lung cancer (n = 1), blunt chest trauma (n = 2) and stenosis (n = 1). Isolated resection of the bifurcation (n = 4), resection of the bifurcation en bloc with the right main bronchus with reconstruction of a "neo-trifurcation" (n = 1), resection of the right main stem bronchus (n = 6), resection of the bronchus intermedius (n = 2) and resection of the middle lobe bronchus (n = 1) were right-sided procedures. Left-sided procedures included resection of the left main stem bronchus (n = 3) and left main stem bronchus resection en bloc with the upper lobe and lower lobe bronchus (n = 2). Follow-up was complete and ranged from 11 to 108 months (median follow-up 62.7 +/- 28.6 months). Morbidity was 26.4 %. The cure was delayed in 1 out of 19 anastomoses. No anastomotic dehiscence was seen. No mortality occurred. Resections were complete except for the resection of the adenoid cystic carcinoma (n = 1, R1 resection). No anastomotic stenosis or recurrence of cancer occurred in the late outcome. CONCLUSIONS: In properly selected patients, traumatic bronchial ruptures, localized malign or benign disease can be safely resected without parenchymal loss. Excellent morbidity and mortality rates and a good long-term outcome can be achieved.

PMID: 20072974 [PubMed - in process]

Basaloid squamous cell carcinoma: two case reports.

Fetched: January 20th, 2010, 9:02am CST

Basaloid squamous cell carcinoma: two case reports.

Cases J. 2009;2:9351

Authors: Vasudev P, Boutross-Tadross O, Radhi J

Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of squamous cell carcinoma (SCC) that occurs preferentially in the upper aerodigestive tract. We present two cases of BSCC, one arising in the conjunctiva and the other arising in a paranasal sinus. Clinical and pathological findings in these two cases, including immunohistochemistry is presented along with brief discussion of literature. To the best of our knowledge, this is the first report of BSCC of the conjunctiva. BSCC of the head and neck should be distinguished from adenoid cystic carcinoma, small cell neuroendocrine carcinoma, basal cell adenocarcinoma, adenosquamous carcinoma, squamous cell carcinoma, spindle cell squamous carcinoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma.

PMID: 20062602 [PubMed - in process]

Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.

Fetched: January 20th, 2010, 9:02am CST

Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland.

Oral Oncol. 2010 Jan 7;

Authors: Dincer N, Tezel GG, Sungur A, Himmetoglu C, Huebner K, Güler G

Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are salivary gland neoplasms with divergent morphological features and clinical behavior. ACC is a basaloid tumor whereas MEC is a glandular epithelial neoplasm. FHIT and WWOX are tumor suppressor genes that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3, respectively. In previous studies, we have shown concordant loss of Fhit and Wwox expression in breast cancer, with significantly more frequent loss in cancers of basal-like phenotype. To determine if there is a similar association in salivary gland neoplasms, we designed a study of MEC and ACC of salivary gland on tissue microarrays (TMA). TMAs were constructed from 25 MEC and 19 ACC of salivary gland. Fhit and Wwox protein expression was assessed by immunohistochemical staining of cores on TMAs. Correlations among immunohistochemical markers and histological type were determined by statistical analyses. Significantly reduced Fhit and Wwox expression was observed in ACC (p=0.002 and p<0.001, respectively). The results suggest that, as for breast cancer, loss of Fhit and Wwox expression might have a role in the pathogenesis of basaloid differentiation in salivary gland neoplasms; alternatively, differences in chromatin structure at chromosome fragile regions might make fragile genes more accessible to DNA damage and rearrangement early during preneoplastic stages of basaloid cancers. Studies of basaloid tumors of other organ systems may show similar results and these findings may have implications for treatment modalities designed for basal-like tumors.

PMID: 20060354 [PubMed - as supplied by publisher]

[Therapeutic options in sinunasal adenoid cystic carcinomas--a case report and review]

Fetched: January 20th, 2010, 9:02am CST

[Therapeutic options in sinunasal adenoid cystic carcinomas--a case report and review]

Laryngorhinootologie. 2009 Oct;88(10):631-8

Authors: Mozet C, Stumpp P, Mekonnen B, Dietz A

BACKGROUND: Adenoid cystic carcinomas (ACC) in sinunasal compartments are often not completely resectable. We discuss both, surgical margins and functional results preoperatively and postoperative options for adjuvant therapy. The former opinion of a resistance of ACC towards chemotherapy or irradiation seems to be outdated, even though consensus about therapeutic strategies is still missing. MATERIAL AND METHODS: We discuss therapeutic options and compare data from literature regarding the best adjuvant therapy with the case of a 25-year-old patient with an advanced ACC of the left fossa pterygopalatina. Further we discuss alternative therapeutic options like neutron irradiation, chemotherapy or targeted therapy. Following the advice from literature, we performed an eye saving tumor resection by a left transmaxilloethmoidale sphenoidectomy via combined trans- und extranasal approach. We accepted close surgical margins for the benefit of the abandonment of dismembering measures and performed an adjuvant radiochemotherapy with taxol and carboplatin. RESULTS: With the described therapeutic strategy we reached an optimal local tumor control with unlimited visus and without functional and cosmetic restrictions up to now. Periodic staging did not show any local tumor progress or metastatic spread hitherto. CONCLUSION: Organ preserving surgery and adjuvant radiochemotherapy even in combination with taxol and carboplatin seems to be a sufficient therapeutic option in treating advanced sinunasal ACC, and might not have any prognostic disadvantages to radical surgery.

PMID: 19813159 [PubMed - indexed for MEDLINE]

Serum soluble CD44v6 levels in patients with oral and maxillofacial malignancy.

Fetched: January 10th, 2010, 2:29pm CST

Serum soluble CD44v6 levels in patients with oral and maxillofacial malignancy.

Oral Dis. 2009 Nov;15(8):570-2

Authors: Chang SM, Xing RD, Zhang FM, Duan YQ

OBJECTIVE: To determine the levels of serum sCD44v6 in patients with oral cancer and evaluate the value of serum sCD44v6 in adjuvant diagnosis, staging and monitoring treatment response in these patients. MATERIALS AND METHODS: A total of 112 hospitalized patients with oral and maxillofacial malignancy and 28 healthy individuals were examined for serum sCD44v6 levels. Venous blood was collected from these patients and the healthy individuals. One week after treatment, venous blood was collected once again in 60 patients with oral and maxillofacial squamous cell carcinoma (OSCC). RESULTS: The sCD44v6 concentration was not significantly different between patients with oral and maxillofacial malignancy and control group (P > 0.05). The levels of serum sCD44v6 in patients with OSCC and salivary carcinoma showed no difference with those in control group (P > 0.05). The sCD44v6 level in patients with stage III and IV disease was higher than that of patients with stage I and II and that of the control group, but the difference was not significant (P > 0.05). Serum sCD44v6 levels in patients with OSCC after treatment became lower than that prevailed during pretreatment (P < 0.05). CONCLUSION: The possible roles of CD44v6 in the diagnosis of oral and maxillofacial malignancy deserve further elucidation and evaluation. Serum sCD44v6 may be a valuable marker in monitoring treatment response in patients with OSCC.

PMID: 19563418 [PubMed - indexed for MEDLINE]

Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report.

Fetched: January 3rd, 2010, 8:22pm CST

Hybrid salivary gland tumor of the upper lip or just an adenoid cystic carcinoma? Case report.

Med Oral Patol Oral Cir Bucal. 2009;15(1):e43-e47

Authors: Mosqueda-Taylor A, Cano-Valdéz AM, Ruiz-González JD, Ortega-Gutiérrez C, Luna-Ortiz K

A 65 year-old male patient with a one year-duration tumoral growth located in the upper lip was diagnosed on incisional biopsy as epithelial-myoepithelial carcinoma. After wide surgical excision the histopathological analysis revealed the lesion was composed predominantly (>90%) of adenoid cystic carcinoma. In new sections it was found a very small and isolated area of adenoid cystic carcinoma at the bottom of the incisional biopsy. As surgical margins were free of lesion, no adjuvant treatment was given. The occurrence of a transitory ischaemic attack at 36 months of follow-up led to a neurological and MRI evaluation, which disclosed a well-defined 3.5x3 cm lesion suggestive of metastasis, located on the right temporal area. The lesion was surgically removed and a histopathological diagnosis of neurocysticercosis was rendered. After 40 months of follow-up there is no evidence of recurrence. Conclusion: True hybrid tumors of salivary glands are rare and treatment in each case should be done according to the component with the higher aggressiveness. However, the occurrence of epithelial-myoepithelial carcinoma areas within an adenoid cystic carcinoma seems to be a frequent finding, and because both lesions share a common origin, some authors consider that this may not be a true hybrid neoplasm but a variant of the latter.

PMID: 20044724 [PubMed - as supplied by publisher]

Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.

Fetched: January 1st, 2010, 4:55pm CST

Mitochondrial mutations in adenoid cystic carcinoma of the salivary glands.

PLoS One. 2009;4(12):e8493

Authors: Mithani SK, Shao C, Tan M, Smith IM, Califano JA, El-Naggar AK, Ha PK

BACKGROUND: The MitoChip v2.0 resequencing array is an array-based technique allowing for accurate and complete sequencing of the mitochondrial genome. No studies have investigated mitochondrial mutation in salivary gland adenoid cystic carcinomas. METHODOLOGY: The entire mitochondrial genome of 22 salivary gland adenoid cystic carcinomas (ACC) of salivary glands and matched leukocyte DNA was sequenced to determine the frequency and distribution of mitochondrial mutations in ACC tumors. PRINCIPAL FINDINGS: Seventeen of 22 ACCs (77%) carried mitochondrial mutations, ranging in number from 1 to 37 mutations. A disproportionate number of mutations occurred in the D-loop. Twelve of 17 tumors (70.6%) carried mutations resulting in amino acid changes of translated proteins. Nine of 17 tumors (52.9%) with a mutation carried an amino acid changing mutation in the nicotinamide adenine dinucleotide dehydrogenase (NADH) complex. CONCLUSIONS/SIGNIFICANCE: Mitochondrial mutation is frequent in salivary ACCs. The high incidence of amino acid changing mutations implicates alterations in aerobic respiration in ACC carcinogenesis. D-loop mutations are of unclear significance, but may be associated with alterations in transcription or replication.

PMID: 20041111 [PubMed - in process]

Intracranial extension of salivary gland tumors.

Fetched: January 1st, 2010, 4:55pm CST

Intracranial extension of salivary gland tumors.

Clin Neuropathol. 2010 Jan-Feb;29(1):9-13

Authors: Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro ML,

Objective: The aim of this report is to describe 3 cases of salivary gland tumors with intracranial extension associated to an extracerebral mass lesion, and to discuss the frequence, pathology and treatment of these very rare localizations. Clinical material: The 3 patients were 1 woman and 2 men, aged 44, 53 and 74 years, respectively. The primary tumors were an adenocarcinoma and a malignant oncocytoma of the parotid gland and an adenoid cystic carcinoma of the submandibular gland. The location of the intradural extra-axial tumor was the middle fossa and temporal region in 2 cases and the cerebellopontine angle in 1. Surgical treatment consisted in the seemingly complete removal of 2 tumors with middle fossa localization and partial removal of the cerebellopontine angle lesion. Radiotherapy was administered in all 3 cases and chemotherapy in 2. Results: 1 patient is alive and free of recurrence 32 months after removal of the intracranial tumor; 2 other patients died 28 months and 12 months postoperatively. Conclusions: The intracranial extension of salivary gland tumors is a very rare event. An aggressive surgical resection followed by radiotherapy is justified in cases with significant intracranial mass lesions and scarce bone and dural involvement.

PMID: 20040327 [PubMed - in process]

Intracranial extension of salivary gland tumors.

Fetched: January 1st, 2010, 4:55pm CST

Intracranial extension of salivary gland tumors.

Clin Neuropathol. 2010 Jan-Feb;29(1):9-13

Authors: Maiuri F, Gangemi M, Giamundo A, Mariniello G, Colella A, Vergara P, Del Basso De Caro ML,

PMID: 20040327 [PubMed - in process]

Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors.

Fetched: January 1st, 2010, 4:55pm CST

Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors.

Head Neck. 2009 Oct;31(10):1297-308

Authors: Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG, Loeffler JS, Chan AW

BACKGROUND: The purpose of this study was to determine treatment outcome and prognostic factors in patients with locally advanced primary sphenoid sinus malignancy treated with proton radiation therapy. METHODS: Between 1991 and 2005, 20 patients with primary sphenoid sinus malignancy received proton beam to a median dose of 76 Gray equivalent. RESULTS: With a median follow-up of 27 months, the 2-year local, regional, and freedom from distant metastasis rates were 86%, 86%, and 50%, respectively. The disease-free and overall-survival rates at 2 years were 31% and 53%, respectively. In multivariate analysis, oropharyngeal involvement (p = .005) and anterior cranial fossa invasion (p = .02) were predictive for poor disease-free survival rate. Brain invasion was predictive for decreased overall-survival rate (p = .05). CONCLUSIONS: Proton radiation therapy results in excellent local control in patients with advanced primary sphenoid sinus malignancy. Brain invasion, involvement of the oropharynx and anterior cranial fossa are important prognostic factors.

PMID: 19536762 [PubMed - indexed for MEDLINE]

Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors.

Fetched: January 1st, 2010, 4:55pm CST

Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors.

Head Neck. 2009 Oct;31(10):1297-308

Authors: Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG, Loeffler JS, Chan AW

PMID: 19536762 [PubMed - indexed for MEDLINE]

Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.

Fetched: December 27th, 2009, 9:49am CST

Comparison of immunohistochemical markers between adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.

J Oral Sci. 2009 Dec;51(4):509-14

Authors: Saghravanian N, Mohtasham N, Jafarzadeh H

Adenoid cystic carcinoma (AdCC) and polymorphous low-grade adenocarcinoma (PLGA) have several common histological and clinicopathological features that may create diagnostic difficulties. In this study, 10 AdCCs, 8 PLGAs, and 5 normal minor salivary glands as a control group were selected. Sections prepared from each tumor were stained using the streptavidin-biotin system for seven marker antigens: carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), muscle-specific actin (MSA), vimentin, S100, p53, and Ki-67. Data analysis showed high expression of CEA, MSA and Ki-67 in AdCCs compared with PLGAs, although CEA expression was limited to luminal cells. Ki-67 was expressed in both luminal and non-luminal cells and MSA only in non-luminal cells. Vimentin and S100 showed stronger expression in PLGAs, the expression of vimentin was more noticeable, being focal and widespread. The immunoreactivities of EMA and P53 were not helpful for distinguishing between the two tumors, although the EMA expression pattern in AdCCs was limited to luminal cells, whereas it was present in both luminal and non-luminal cells in PLGAs. Thus, immunohistochemistry can be helpful for differential diagnosis of AdCC and PLGA, particularly that for CEA, vimentin, and Ki-67. (J Oral Sci 51, 509-514, 2009).

PMID: 20032601 [PubMed - in process]

Basal Cell Adenocarcinoma of a Hard Palate Minor Salivary Gland: Case Report and Review of the Literature.

Fetched: December 27th, 2009, 9:49am CST

Basal Cell Adenocarcinoma of a Hard Palate Minor Salivary Gland: Case Report and Review of the Literature.

Head Neck Oncol. 2009 Dec 23;1(1):41

Authors: Ward BK, Seethala RR, Barnes EL, Lai SY

ABSTRACT: OBJECTIVE: Basal cell adenocarcinoma of a minor salivary gland is extremely rare. The goal of this report is to increase awareness of this rare disease and to review and discuss the differential diagnosis and important considerations in treatment. Study Design: Case report and review of the literature. METHODS: Case report of a basal cell adenocarcinoma of a hard palate minor salivary gland and review of the literature of basal cell adenocarcinoma. RESULTS: Basal cell adenocarcinomas are slow-growing tumours that most commonly involve the parotid gland and very rarely involve minor salivary glands. Although recurrence rates for these tumours are high, mortality rates are low. Histological diagnosis is important to distinguish this tumour from adenoid cystic carcinoma given the significant difference in disease prognosis. CONCLUSIONS: Diagnosis of these tumours must be made histologically. Recommended treatment options include wide local excision with radiotherapy reserved for close surgical margins or for local recurrence.

PMID: 20030819 [PubMed - as supplied by publisher]

Adenoid Cystic Carcinoma of the Breast: A Review of a Single Institution's Experience.

Fetched: December 27th, 2009, 9:49am CST

Adenoid Cystic Carcinoma of the Breast: A Review of a Single Institution's Experience.

Breast J. 2009 Dec 16;

Authors: Sarnaik AA, Meade T, King J, Acs G, Hoover S, Cox CE, Bradford Carter W, Laronga C

PMID: 20030648 [PubMed - as supplied by publisher]

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors.

Fetched: December 27th, 2009, 9:49am CST

Immunohistochemical study of androgen, estrogen and progesterone receptors in salivary gland tumors.

Braz Oral Res. 2009 Oct-Dec;23(4):393-8

Authors: Ito FA, Ito K, Coletta RD, Vargas PA, Lopes MA

The aim of this work was to study the immunohistochemical expression of androgen receptor, estrogen receptor and progesterone receptor in pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas of salivary glands. A total of 41 pleomorphic adenomas, 30 Warthin's tumors, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas were analyzed, and the immunohistochemical expression of these hormone receptors were assessed. It was observed that all cases were negative for estrogen and progesterone receptors. Androgen receptor was positive in 2 cases each of pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma. In conclusion, the results do not support a role of estrogen and progesterone in the tumorigenesis of pleomorphic adenomas, Warthin's tumors, mucoepidermoid carcinomas and adenoid cystic carcinomas. However, androgen receptors can play a role in a small set of salivary gland tumors, and this would deserve further studies.

PMID: 20027446 [PubMed - in process]

Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results.

Fetched: December 27th, 2009, 9:49am CST

Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results.

Arch Otolaryngol Head Neck Surg. 2009 Dec;135(12):1219-24

Authors: Hanna E, DeMonte F, Ibrahim S, Roberts D, Levine N, Kupferman M

OBJECTIVE: To evaluate the oncologic outcomes of patients with sinonasal cancer treated with endoscopic resection. DESIGN: Retrospective review. SETTING: Tertiary care academic cancer center. PATIENTS: All patients with biopsy-proved malignant neoplasm of the sinonasal region who were treated with endoscopic resection between 1992 and 2007 were included in the study, and their charts were reviewed for demographics, histopathologic findings, treatment details, and outcome. MAIN OUTCOME MEASURES: Oncologic outcomes, including disease recurrence and survival. RESULTS: Of a total of 120 patients, 93 (77.5%) underwent an exclusively endoscopic approach (EEA) and 27 (22.5%) underwent a cranioendoscopic approach (CEA) in which the surgical resection involved the addition of a frontal or subfrontal craniotomy to the transnasal endoscopic approach. Of the 120 patients, 41% presented with previously untreated disease, 46% presented with persistent disease that had been partially resected, and 13% presented with recurrent disease after prior treatment. The most common site of tumor origin was the nasal cavity (52%), followed by the ethmoid sinuses (28%). Approximately 10% of the tumors had an intracranial epicenter, most commonly around the olfactory groove. Tumors extended to or invaded the skull base in 20% and 11% of the patients, respectively. An intracranial epicenter (P < .001) and extension to (P = .001) or invasion of (P < .001) the skull base were significantly more common in patients treated with CEA than in those treated with EEA. The primary T stage was evenly distributed across all patients as follows: T1, 25%; T2, 25%; T3, 22%; and T4, 28%. However, the T-stage distribution was significantly different between the EEA group and the CEA group. Approximately two-thirds (63%) of the patients treated with EEA had a lower (T1-2) disease stage, while 95% of patients treated with CEA had a higher (T3-4) disease stage (P < .001). The most common tumor types were esthesioneuroblastoma (17%), sarcoma (15%), adenocarcinoma (14%), melanoma (14%), and squamous cell carcinoma (13%). Other, less common tumors included adenoid cystic carcinoma (7%), neuroendocrine carcinoma (4%), and sinonasal undifferentiated carcinoma (2%). Microscopically positive margins were reported in 15% of patients. Of the 120 patients, 50% were treated with surgery alone, 37% received postoperative radiation therapy, and 13% were treated with surgery, radiation therapy, and chemotherapy. The overall surgical complication rate was 11% for the whole group. Postoperative cerebrospinal fluid leakage occurred in 4 of 120 patients (3%) and was not significantly different between the CEA group (1 of 27 patients) and the EEA group (3 of 93 patients) (P > .99). The cerebrospinal fluid leak resolved spontaneously in 3 patients, and the fourth patient underwent successful endoscopic repair. With a mean follow-up of 37 months, 18 patients (15%) experienced local recurrence, with a local disease control of 85%. Regional and distant failure occurred as the first sign of disease recurrence in 6% and 5% of patients, respectively. The 5- and 10-year disease-specific survival rates were 87% and 80%, respectively. Disease recurrence and survival did not differ significantly between the EEA group and the CEA group. CONCLUSIONS: To the best of our knowledge, this is the largest US series to date of patients with malignant tumors of the sinonasal tract treated with endoscopic resection. Our results suggest that, in well-selected patients and with appropriate use of adjuvant therapy, endoscopic resection of sinonasal cancer results in acceptable oncologic outcomes.

PMID: 20026819 [PubMed - in process]

The Effect of Proteoglycans Inhibited by RNA Interference on Metastatic Characters of Human Salivary Adnoid Cystic Carcinoma.

Fetched: December 27th, 2009, 9:49am CST

The Effect of Proteoglycans Inhibited by RNA Interference on Metastatic Characters of Human Salivary Adnoid Cystic Carcinoma.

BMC Cancer. 2009 Dec 21;9(1):456

Authors: Shi H, Wang J, Dong F, Wang X, Li H, Hou Y

ABSTRACT: BACKGROUND: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignancies of salivary gland. Recurrence or/and early metastasis is its biological properties. In SACC, neoplastic myoepithelial cells secrete proteoglycans unconventionally full of the cribriform or tubular and glandular structures of SACC. Literatures have demonstrated that extracellular matrix provided an essential microenvironment for the biological behavior of SACC. However, there is rare study of the effect of proteoglycans on the potential metastasis of SACC. In this study, human xylosyltransferase-I (XTLY-I) gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi) to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M). The impact of down-regulated proteoglycans on the metastasis characters of SACC-M cells was analyzed and discussed. This research could provide a new idea for the clinical treatment of SACC. METHODS: The eukaryotic expression vector of short hairpin RNA (shRNA) targeting XTLY-I gene was constructed and transfected into SACC-M cells. A stably transfectant cell line named SACC-M-WJ4 was isolated. The XTLY-I expression was measured by real-time PCR and Western blot; the reduction of proteoglycans was measured. The invasion and metastasis of SACC-M-WJ4 cells were detected; the effect of down-regulated proteoglycans on the potential lung metastasis of nude mice was observed, respectively. RESULTS: The shRNA plasmid targeting XTLY-I gene showed powerful efficiency of RNAi. The mRNA level of target gene decreased by 86.81%, the protein level was decreased by 80.10%, respectively. The silence of XTLY-I gene resulted in the reduction of proteoglycans significantly in SACC-M-WJ4 cells. The inhibitory rate of proteoglycans was 58.17% (24 h), 66.06% (48 h), 57.91% (72 h), 59.36% (96 h), and 55.65% (120 h), respectively. The reduction of proteoglycans suppressed the adhesion, invasion and metastasis properties of SACC-M cells, and decreased the lung metastasis of SACC-M cells markedly either. CONCLUSION: The data suggested that the silence of XTLY-I gene in SACC-M cells could suppress proteoglycans biosynthesis and secretion significantly. The reduction of proteoglycans inhibited cell adhesion, invasion and metastasis of SACC-M cells. There is a close relationship between proteoglycans and the biological behavior of SACC.

PMID: 20025737 [PubMed - as supplied by publisher]

Malignant Tumors of the Anterolateral Skull Base.

Fetched: December 22nd, 2009, 8:01am CST

Malignant Tumors of the Anterolateral Skull Base.

Neurosurgery. 2010 Jan;66(1):102-112

Authors: Hentschel SJ, Vora Y, Suki D, Hanna EY, Demonte F

OBJECTIVE: Malignancies of the anterolateral skull base are clinically and pathologically distinct from those of the central anterior skull base and the temporal bone. The purpose of this report is to describe the outcomes and complications after skull base surgery and multimodality therapy in a group of patients with anterolateral skull base malignancies. PATIENT DATA AND METHODS: The mean duration of follow-up for living patients was 57.2 months (median, 56.8 months). The median age of the 52 patients who met the inclusion criteria for this study was 47 years (range, 1-81 years). The most common presenting feature was cranial nerve palsy (60%). Of these cranial nerve palsies, trigeminal neuropathies causing facial numbness were the most common, with V2 being affected in 35%, V3 affected in 33%, and V1 affected in 17%. Abducens neuropathy was present in 14% of patients. The most frequently occurring pathologies after the various sarcomas were squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC) in 23% and 14% of patients, respectively. Of the 30 sarcomas, 16 were classified as low grade and 14 were classified as high grade. RESULTS: Complications of treatments were identified in 16 patients (31%). Ten patients had a single complication, whereas 6 patients experienced multiple complications. The most common complications were a new or worsened cranial nerve deficit (n = 4), pneumonia (n = 4), and flap necrosis (n = 3). Recurrence after the treatment associated with the index surgery occurred in 37 patients (71%). The recurrence was local in 30 patients (58%), both local and distant (metastatic) in 4 patients (8%), and only distant in 3 patients (12%). The median progression-free survival (PFS) was 2.1 years (range, 1.2-3.0 years). Median PFS times of 0.6 and 1.6 years were noted for patients with high-grade sarcoma (HGS) and low-grade sarcoma (LGS), respectively. The mean PFS (median not reached) for the patients with SCC was 4.6 years, whereas the median PFS for patients with ACC was 3.3 years. The overall 2- and 5-year survivals for all patients were 81% and 53% (median, 5.0 years; 95% confidence interval, 3.9-6.1 years), respectively. The median survival for patients with nonsarcomas was 6.9 years, the 2-year survival was 82%, and the 5-year survival was 55%. Patients with HGS survived the shortest time (median, 3.3 years; 2-year, 64%; 5-year, 27%), whereas those patients with LGS had an intermediate survival (median, 5.3 years; 2-year, 94%, 5-year, 72%). CONCLUSION: It is our belief that anterolateral skull base malignancies comprise a distinct group of tumors. These lesions should be analyzed separately from central anterior skull base lesions and temporal bone malignancies. With a multimodality treatment protocol, acceptable survivals may be obtained that are comparable to results that have been reported for tumors involving less difficult areas of the skull base.

PMID: 20023541 [PubMed - as supplied by publisher]

Permalink for 'High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study.'

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study.

Fetched: December 22nd, 2009, 8:01am CST

High Grade Transformation in Adenoid Cystic Carcinoma of the Parotid: Report of a Case with Cytologic, Histologic and Immunohistochemical Study.

Head Neck Pathol. 2009 Dec;3(4):310-314

Authors: Malhotra KP, Agrawal V, Pandey R

Adenoid cystic carcinoma (ACC) constitutes about 4% of salivary epithelial tumors and is the second common malignant epithelial salivary gland tumor involving both the major and minor salivary glands. High grade transformation in ACC is a recently recognized entity with only a few cases reported in literature. We report the first case of ACC with high grade transformation involving the parotid. A 54-year-old man with a history of right parotid painful swelling from 1.5 years presented with recent increase in size of the swelling and facial paresis of 2 months duration. The locally invasive salivary neoplasm was composed predominantly of an undifferentiated carcinoma with foci of conventional ACC occupying less than 10% of tumor area. Immunohistochemical study of the undifferentiated component as compared to conventional ACC showed greater over-expression of p53 and Ki-67. Her-2/Neu was negative in both components. Recognition of occasional clusters of basaloid cells and hyaline globules in association with larger poorly differentiated malignant cell population in aspiration smears can help in cytological diagnosis. The acquisition of high proliferation index and over-expression of p53 may be the probable factors involved in the pathogenesis of high grade transformation in a conventional ACC.

PMID: 20016788 [PubMed - as supplied by publisher]

Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report.

Fetched: December 22nd, 2009, 8:01am CST

Fine needle aspiration cytopathology of primary solid adenoid cystic carcinoma of the lung: a case report.

Acta Cytol. 2009 Nov-Dec;53(6):707-10

Authors: Ozkara SK, Turan G

BACKGROUND: Adenoid cystic carcinoma (ACC) is a rare, distinctive salivary gland malignant neoplasm arising infrequently as a primary tumor in the lung. Cytomorphology of lung primary ACC has been rarely reported. To the best of our knowledge, cytopathologic features of the solid type of ACC have not been described as a primary lung tumor. CASE: A case of solid-type primary pulmonary ACC arising in the upper segment of the left mainstem bronchus, suggestively diagnosed cytopathologically by bronchoscope-guided fine needle aspiration (FNA), is presented. Cytopathologic differential diagnoses of ACC with other, more common primary neoplasms of the lung are discussed. FNA smears exhibited a normocellular specimen with several large, densely cellular tissue fragments and individual cells, homogeneous and without prominent atypia. Nuclei were round to oval, with finely granular chromatin. Nucleoli were either absent or inconspicious. The nuclear to cytoplasmic ratio was high. Cytoplasm was minimal; chromatin was bland, with rare chromocenters. There was no nuclear molding. Staining the air-dried smears with May-Grünwald-Giemsa stain revealed metachromatic, magenta material not in spherules or cords but as shapeless structures surrounded by tumor cells. CONCLUSION: A preoperative cytopathologic diagnosis of poorly differentiated primary pulmonary ACC can enhance surgical planning and success of tumor resection.

PMID: 20014565 [PubMed - in process]

Adenoid cystic carcinoma of the trachea metastatic to the nasal cavity: A case report.

Fetched: December 22nd, 2009, 8:01am CST

Adenoid cystic carcinoma of the trachea metastatic to the nasal cavity: A case report.

Ear Nose Throat J. 2009 Dec;88(12):E9-E11

Authors: Khorsandi AS, Silberzweig JE, Wenig BM, Urken ML, Holliday RA

Cases of carcinoma metastatic to the nasal cavity are rare. We report the case of a 63-year-old woman with a metastasis to the nasal cavity from a primary tracheal adenoid cystic carcinoma (ACC). The nasal tumor was treated with surgical resection. No evidence of any local recurrence was observed at 4 years of follow-up. To the best of our knowledge, no case of a tracheal ACC metastatic to the nasal cavity has been previously reported in the literature. Although rare, metastatic disease to the nasal cavity should be considered in patients who have a known primary carcinoma elsewhere and who present with nasal symptoms.

PMID: 20013669 [PubMed - in process]

Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004.

Fetched: December 22nd, 2009, 8:01am CST

Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004.

Acta Oncol. 2009 Dec 10;

Authors: Thorup C, Sebbesen L, Danø H, Leetmaa M, Andersen M, Buchwald C, Kristensen CA, Bentzen J, Godballe C, Johansen J, Grau C

Abstract Objective. To evaluate the treatment outcome for sino-nasal carcinomas in Denmark from 1995-2004 and compare the results to the previous Danish survey covering 1982-1991. Design. Retrospective follow-up. Materials and methods. In the five Danish head and neck oncology centres, charts of all consecutive patients with sino-nasal carcinomas were reviewed and data extracted to a common database. Altogether 242 patients from the period 1995-2004 were identified. Of these 162 (67%) were male and 80 (33%) female. Histologies included squamous cell carcinoma (55%), adenocarcinoma (28.5%), adenoid-cystic carcinoma (5.0%), undifferentiated carcinoma (4.5%), transitiocellular carcinoma (1.7%), mucoepidermoid carcinoma (0.8%), neuroendocrine carcinoma (2.5%), small cell carcinomas (1.2%) and carcinomas not otherwise specified (0.8%). Treatments included radiotherapy alone 79 (33%), surgery alone 29 (12%), combined surgery and radiotherapy 96 (40%), palliative/no treatment 38 (16%). A total of 204 (86%) patients were treated with curative intent. Results. Of the 204 patients treated with curative intent, 94 (46%) relapsed. Most failures were in T-site (63, 30%). N-site failures were 10 (5%) and M-site failures six (3%). Failure occurring in T+N-site, T+M-site, N+M-site and T+N+M-site were seven (3%), two (1%), one (0.5%) and five (3%) respectively. The 5-year actuarial local, nodal and loco-regional control rates were 55+/-4%, 86+/-3%, 49+/-4%, respectively. The overall 5-year actuarial survival rate for the entire cohort was 47+/-3%, and the corresponding cancer-specific 5-year actuarial survival rate was 57+/-3%. Female gender, nasal cavity tumour, adenocarcinoma and low clinical stage were significant positive prognostic factors in univariate analysis. A Cox multivariate analysis showed that only tumour site and clinical stage were independent significant prognostic factors. Conclusion. The current series has confirmed stage and tumour site as independent prognostic factors. Compared to the previous Danish survey covering the period 1982-1991, the overall survival and cancer-specific survival rates have improved significantly.

PMID: 20001493 [PubMed - as supplied by publisher]

Permalink for 'Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction.'

Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction.

Fetched: December 22nd, 2009, 8:01am CST

Tumor mapping in 2 large multigenerational families with CYLD mutations: implications for disease management and tumor induction.

Arch Dermatol. 2009 Nov;145(11):1277-84

Authors: Rajan N, Langtry JA, Ashworth A, Roberts C, Chapman P, Burn J, Trainer AH

OBJECTIVES: To comprehensively ascertain the extent and severity of clinical features in affected individuals from 2 large families with proven heterozygous mutations in the CYLD locus and to correlate these findings with the 3 appendageal tumor predisposition syndromes (familial cylindromatosis, Brooke-Spiegler syndrome, and multiple familial trichoepitheliomas) known to be associated with such germline mutations. DESIGN: Interfamilial and intrafamilial observational study. SETTING: Tertiary genetic and dermatology referral center. PARTICIPANTS: Thirty-four individuals recruited from 2 large multigenerational families with CYLD mutations. Clinical details, history, and tumor maps were obtained from all participants; in 18, the information was corroborated by detailed clinical examination. MAIN OUTCOME MEASURES: Tumor density, distribution and histologic findings, associated medical conditions, patient symptoms, and impact of disease on quality of life. RESULTS: The severity of penetrance and phenotype varied within families. Although an approximately equal female to male predisposition was noted, 5 women and 1 man (of 26 patients surveyed [23%]) had undergone total scalp removal. The average age at onset was 16 years (range, 8-30 years). Symptoms reported by affected patients included painful tumors (in 12 of 23 patients [52%] who answered the question), conductive deafness, and sexual dysfunction. Of the 26 surveyed patients, tumors were noted on the scalp in 21 (81%), on the trunk in 18 (69%), and in the pubic area in 11 (42%). Tumor mapping provided clinical evidence that correlated with hormonally stimulated hair follicles being particularly vulnerable to loss of heterozygosity and tumor induction. CONCLUSIONS: The burden of disease at sites other than the head and neck appears to be underreported in the literature and greatly affects quality of life. Differentiation between the clinical diagnoses has little prognostic or clinical utility in genetic counseling, even within individuals from the same family. Thus, we suggest an encompassing diagnosis of "CYLD cutaneous syndrome." Finally, the clinical distribution of tumors suggests that hormonal factors may play an important role in tumor induction in these patients.

PMID: 19917957 [PubMed - indexed for MEDLINE]

[Surgery on cylindroma of the external auditory canal]

Fetched: December 22nd, 2009, 8:01am CST

[Surgery on cylindroma of the external auditory canal]

Ugeskr Laeger. 2009 Nov 2;171(45):3280-2

Authors: Juhlin J

Cylindromas are rare benign tumours arising from sweat glands in the skin. They occur as multiple tumours (as in Brooke-Spieglers syndrome) and solitary tumours. They most commonly occur on the head and neck and may appear in the external auditory canal causing hearing loss. We present such a case and discuss its pathological and clinical features. The patient was treated with local surgical excision.

PMID: 19887058 [PubMed - indexed for MEDLINE]

Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck.

Fetched: December 22nd, 2009, 8:01am CST

Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18740-4

Authors: Persson M, Andrén Y, Mark J, Horlings HM, Persson F, Stenman G

The transcription factor gene MYB was identified recently as an oncogene that is rearranged/duplicated in some human leukemias. Here we describe a new mechanism of activation of MYB in human cancer involving gene fusion. We show that the t(6;9)(q22-23;p23-24) translocation in adenoid cystic carcinomas (ACC) of the breast and head and neck consistently results in fusions encoding chimeric transcripts predominantly consisting of MYB exon 14 linked to the last coding exon(s) of NFIB. The minimal common part of MYB deleted as the result of fusion was exon 15 including the 3'-UTR, which contains several highly conserved target sites for miR-15a/16 and miR-150 microRNAs. These microRNAs recently were shown to regulate MYB expression negatively. We suggest that deletion of these target sites may disrupt repression of MYB leading to overexpression of MYB-NFIB transcripts and protein and to activation of critical MYB targets, including genes associated with apoptosis, cell cycle control, cell growth/angiogenesis, and cell adhesion. Forced overexpression of miR-15a/16 and miR-150 in primary fusion-positive ACC cells did not significantly alter the expression of MYB as compared with leukemic cells with MYB activation/duplication. Our data indicate that the MYB-NFIB fusion is a hallmark of ACC and that deregulation of the expression of MYB and its target genes is a key oncogenic event in the pathogenesis of ACC. Our findings also suggest that the gain-of-function activity resulting from the MYB-NFIB fusion is a candidate therapeutic target.

PMID: 19841262 [PubMed - indexed for MEDLINE]

[276 cases of horizontal infrahyoid myocutaneous flap]

Fetched: December 22nd, 2009, 8:01am CST

[276 cases of horizontal infrahyoid myocutaneous flap]

Rev Stomatol Chir Maxillofac. 2009 Jun;110(3):135-7

Authors: Ricard AS, Laurentjoye M, Faucher A, Zwetyenga N, Siberchicot F, Majoufre-Lefebvre C

INTRODUCTION: The infrahyoid myocutaneous flap was described by Wang et al. in 1986. The horizontal design of the skin paddle is a modification of this technique allowing for a smaller scar. We have been systematically using this modified technique for 10 years. We had for aim to describe the interest of the horizontal infrahyoid myocutaneous flap for cervicofacial carcinology. PATIENTS AND METHODS: A horizontal infrahyoid myocutaneous flap procedure was performed in 276 cervicofacial carcinology patients for lesions of the mouth floor, the mandibular gum, the oropharynx and the tongue between March 1997 and March 2007. RESULTS: No complications were observed in 252 patients. No patient presented with total flap necrosis. DISCUSSION: Modifying the infrahyoid myocutaneous flap technique with a horizontal design of the skin paddle does not modify the reliability of the flap and prevents more extensive scars. The main indications of this technique are defects of the mouth floor, the tongue and the oropharynx.

PMID: 19403148 [PubMed - indexed for MEDLINE]

[Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]

Fetched: December 22nd, 2009, 8:01am CST

[Management of whole-scalp tumour: the Poncet-Spiegler cylindroma or turban tumour]

Rev Stomatol Chir Maxillofac. 2009 Apr;110(2):109-12

Authors: Alix T, Labbé D, Caquant L, Comoz F, Compère JF, Bénateau H

INTRODUCTION: The Poncet-Spiegler cylindroma (PSC) is a benign annexal cutaneous tumor which preferentially develops on the scalp, neck, or forehead. Localizations may be isolated or multiple and often affect the young adult. The lesions grow progressively. When the scalp is completely involved, it presents as a "turban tumor". Treatment is surgery and may be difficult when the tumor is extended. We report the management of turban tumor. OBSERVATION: A 25 year-old female patient was first treated by partial scalp nodule exeresis and histology documented a PSC. She was lost to follow-up. But 9 years later, she was managed for a turban like PSC. The treatment was a complete scalp exeresis and secondary reconstruction with a skin graft. Follow-up was uneventful with a progressive functional and cosmetic improvement and after 2 years, there was no relapse. DISCUSSION: As for most tumors, management depends on the size of the PSC. An aggressive surgical treatment must be considered if the PSC is extended. In case of turban tumor, total scalp exeresis and secondary reconstruction with a skin graft is recommended.

PMID: 19328506 [PubMed - indexed for MEDLINE]

Permalink for 'Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems.'

Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems.

Fetched: December 9th, 2009, 7:36am CST

Metastasis-associated genes in oral squamous cell carcinoma and salivary adenoid cystic carcinoma: a differential DNA chip analysis between metastatic and nonmetastatic cell systems.

Cancer Genet Cytogenet. 2010 Jan 1;196(1):14-22

Authors: Maruyama S, Cheng J, Yamazaki M, Zhou XJ, Zhang ZY, He RG, Saku T

Overall modes of differential gene expressions were analyzed between human oral/salivary carcinoma cell systems with (MK-1 and ACCM) and without (ZK-1/ZK-2 and ACC2/ACC3) metastatic potential by using micro-array analysis with cancer-associated DNA chips to determine the kinds of genes associated with metastatic behaviors. MK-1 and/or ACCM showed lower levels of gene expression in extracellular matrix-related molecules, such as collagen type IV, laminin, and adhesion molecules such as cadherin 2, but higher levels of genes which control extracellular matrix degradation, such as MMP 9, as well as cell growth and cycle, such as FGF7 and cyclin D1. Among the differentially expressed genes, similar protein expression tendencies for FGF7, laminin, cyclin D1, and collagen type IV were confirmed by immunofluorescence. Metastatic potentials of oral/salivary carcinoma cells seem to have resulted from certain combinations of over-/underexpression of the genes, which were responsible for extracellular matrix metabolism and cell growth in particular.

PMID: 19963131 [PubMed - in process]

[Clinical analysis of adenoid cystic carcinoma of external auditory canal]

Fetched: December 9th, 2009, 7:36am CST

[Clinical analysis of adenoid cystic carcinoma of external auditory canal]

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun;44(6):444-8

Authors: Zhao FF, Wang JL, Wu WM, Huang DL, Dai P, Yang SM, Han WJ, Han DY

OBJECTIVE: To explore methods of treatment for adenoid cystic carcinoma of external auditory canal, and discuss the correlating factors that effect prognosis. METHODS: A retrospective analysis of 19 cases of adenoid cystic carcinoma of external auditory canal treated from 1988 to 2004 was carried out. Based on University of Pittsburgh TNM staging system of external auditory canal carcinoma, 19 cases were classified into groups as 5 cases in T1, 2 in T2, 6 in T3, and 6 in T4. Local resection was performed in cases in stage T1 and T2, while radical mastoidectomy or temporal bone resection was performed in stage T3 and T4. Radiotherapy was applied after operation. Relapsed cases with isolated metastasis were treated by surgery. Multiple metastasis were treated with radiotherapy. RESULTS: The follow-up time is from 6 months to 19 years, and the median is 44 months. There're 8 cases with more than 5 years' follow-up. Twelve patients relapsed and 7 had metastasis but 4 died. The cases with positive incisal edge after first operation relapsed even treated with radiotherapy. In recurrent cases, 9 cases received more than 2 operations, 8 more than 3, and 4 received 4 operations. CONCLUSIONS: The adenoid cystic carcinoma of external auditory canal grows insidiously, and relapses frequently. But the patients can live long with neoplasm implanted. A wide surgical excision combined with post operative radiotherapy was proposed, and negative incision edge should be confirmed. Recurrent cases can be treated with several operations to elongate survival. Multiple relapses will cause metastasis more frequently. Metastasis is the main reason to cause death.

PMID: 19954012 [PubMed - in process]

Permalink for 'Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.'

Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.

Fetched: December 9th, 2009, 7:36am CST

Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.

Int J Oral Maxillofac Surg. 2009 Nov 29;

Authors: Tian Z, Li L, Wang L, Hu Y, Li J

There is little information in the English-language literature about the epidemiology of salivary gland neoplasms in the eastern Chinese population. A large retrospective study (6982 primary salivary tumors during 23 years) was carried out to investigate the clinicopathological features (tumor location, patient sex and age) of these tumors in this population. 3593 tumors were in males and 3389 in females. Pleomorphic adenoma (69%) was the most common tumor and 20% were located in minor glands. 92% of Warthin's tumors occurred in males. Malignant tumors were predominantly adenoid cystic carcinoma (30%) and mucoepidermoid carcinoma (30%). Incidences of lymphoepithelial carcinomas (5%) and polymorphous low-grade adenocarcinoma (1%) of malignant tumors were identified. 28% of tumors originated from minor glands. Most findings were similar to those in the literature, with some variations. The salivary tumors slightly predominated in males. Relatively higher incidences of minor gland tumors and specifically of pleomorphic adenoma in minor glands were noted. Adenoid cystic carcinoma and mucoepidermoid carcinoma constituted the most common malignancies. There was a high incidence of lymphoepithelial carcinomas but a low incidence of polymorphous low-grade adenocarcinoma. The historical significant male predominance of Warthin's tumor was confirmed.

PMID: 19951834 [PubMed - as supplied by publisher]

Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management.

Fetched: December 9th, 2009, 7:36am CST

Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management.

J Pediatr Surg. 2009 Nov;44(11):e1-4

Authors: Romão RL, de Barros F, Maksoud Filho JG, Gonçalves ME, Cardoso S, Tannuri AC, Tannuri U

Primary tracheal malignant neoplasms are very rare. Histologically, squamous cell and adenoid cystic carcinomas are the most common types of malignant primary tracheal tumors when all age groups are studied. In the past 5 years, we treated 2 children with tracheal mucoepidermoid carcinoma. Herein we report both cases and review the literature on the subject with particular emphasis on diagnosis and surgical management.

PMID: 19944203 [PubMed - in process]

Papillary renal cell carcinoma with "Hyaline globules" simulating adenoid cystic carcinoma.

Fetched: November 27th, 2009, 11:17am CST

Papillary renal cell carcinoma with "Hyaline globules" simulating adenoid cystic carcinoma.

Diagn Cytopathol. 2009 Nov 23;

Authors: Eluri S, Ali SZ

PMID: 19937763 [PubMed - as supplied by publisher]

Primary malignant tumors of orofacial region at Benghazi, Libya: A 17 years review.

Fetched: November 27th, 2009, 11:17am CST

Primary malignant tumors of orofacial region at Benghazi, Libya: A 17 years review.

Cancer Epidemiol. 2009 Nov 20;

Authors: Subhashraj K, Orafi M, Nair KV, El-Gehani R, Elarbi M

The aim of this study was to systematically analyze the clinical presentations of orofacial malignant tumors in a Libyan population over a period of 17 years and compare the results with the reports from other countries. During the study period, tumors of epithelial origin were found in 160 patients (82%), followed by tumors of immune system, 22 (11%) and tumors of mesenchymal origin, 14 (7%). Of the total malignant tumors, 115 were men and 81 were women and the male to female ratio was 1.41:1. Malignant non-odontogenic tumors were seen in 194 patients (99%) and malignant odontogenic tumors were seen in 2 patients (1%). Among the epithelial tumors, squamous cell carcinoma (50.6%) was the most common neoplasm, followed by mucoepidermoid carcinoma (15%) and adenoid cystic carcinoma (8.7%). The incidence of oral malignancy is impressively low with respect to the corresponding levels in other countries in Africa and some European countries.

PMID: 19932650 [PubMed - as supplied by publisher]

[Polymorphous low-grade adenocarcinoma: about two cases]

Fetched: November 27th, 2009, 11:17am CST

[Polymorphous low-grade adenocarcinoma: about two cases]

Tunis Med. 2009 Jun;87(6):403-6

Authors: Ayadi L, Chaâbouni S, Dhouib H, Abbès K, Dhouib M, Makni S, Abdelmoula M, Ghorbel A, Khabir A, Boudawara T

BACKGROUND: Polymorphous low-grade adenocarcinoma (APBG) is a variant of malignant tumour of minor salivary glands usually arising in the palate. AIM: Our aim is to discuss morphology, evolution and differential diagnosis of this rare tumour. CASE REPORTS: The first case interested a 65-year-old-woman admitted for a two-months-history of a right submaxillary swelling. Examination found a tumour of the right side of the palate. A biopsy concluded to a pleomorphic adenoma. Giving that the mass enlarged, a surgical resection carrying off the thyroid with a bilateral neck dissection was performed. Diagnosis was an APBG partially resected with lymph node metastasis. The patient received adjuvant radiotherapy. Local recurrence appeared 28 months after treatment. The second case interested a 57-year-old-woman who consulted for a 12-year-history of a swelling of the lower lip. Clinical examination showed a painless nodule measuring 2 cm located in the mucosal side of the lower lip. An excisional biopsy was performed. Pathologic examination concluded to an APBG completely resected. The patient had no evidence of disease with a follow-up of 54 months. CONCLUSION: APBG is characterised by a morphologic diversity and a cytologic uniformity that may cause a diagnostic dilemma especially with adenoid cystic carcinoma and pleomorphic adenoma. Its aggressiveness is assessed by its local infiltrative growth pattern requiring a wide surgical excision.

PMID: 19927787 [PubMed - in process]

Adenoid cystic carcinoma of the external auditory canal.

Fetched: November 27th, 2009, 11:17am CST

Adenoid cystic carcinoma of the external auditory canal.

J Coll Physicians Surg Pak. 2009 Nov;19(11):726-8

Authors: Arshad MH, Khalid U, Ghaffar S

This is a rare case of a young male with biopsy proven adenoid cystic carcinoma of the external auditory canal who underwent excision of the lesion with superficial parotidectomy sparing the facial nerve. Histopathology showed perineural invasion, which is a diagnostic hallmark of adenoid cystic carcinoma. Clinical examination, chest X-ray and CT scan showed no signs of recurrence or metastasis 2 years postoperatively.

PMID: 19889272 [PubMed - in process]

Sialoblastoma in adults: distinction from adenoid cystic carcinoma.

Fetched: November 27th, 2009, 11:17am CST

Sialoblastoma in adults: distinction from adenoid cystic carcinoma.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Oct 30;

Authors: Dardick I, Daley TD, McComb RJ

Essentially, sialoblastoma is a disease of infancy with the oldest case presenting at 4 years of age. About one third of pediatric sialoblastoma cases will have a cribriform growth pattern. No adult cases have been reported with a specific diagnosis of sialoblastoma. If even focal cribriforming were present, such cases have undoubtedly been diagnosed as adenoid cystic carcinoma. Such was the circumstance in the 3 adult tumors presented in this report. Each case, however, has the primitive histopathology with discrete nests of basaloid tumor cells, associated bilayered ductal structures and the fibromyxoid stroma characteristic for sialoblastoma with its resemblance to fetal salivary gland or salivary gland with arrested development. One key example has 28-year follow-up. Sialoblastoma, whether in a child or adult with or without a cribriform growth pattern, appears to have a more favorable prognosis than adenoid cystic carcinoma. Aspects of the histological differential diagnosis of these 2 tumors are discussed.

PMID: 19880331 [PubMed - as supplied by publisher]

Oral rehabilitation with osseointegrated implants in oncologic patients.

Fetched: November 27th, 2009, 11:17am CST

Oral rehabilitation with osseointegrated implants in oncologic patients.

J Oral Maxillofac Surg. 2009 Nov;67(11):2485-96

Authors: Cuesta-Gil M, Ochandiano Caicoya S, Riba-García F, Duarte Ruiz B, Navarro Cuéllar C, Navarro Vila C

PURPOSE: The esthetic and functional rehabilitation of oncologic patients subjected to major resection surgery constitutes one of the greatest challenges for the head and neck surgeon. Immediate bone reconstruction with microsurgical free tissue transfer and dental implants has constituted a genuine revolution in the management of such patients. MATERIALS AND METHODS: We present a series of 111 oncologic patients, involving a total of 706 implants, who underwent reconstruction with pedicled or free microsurgical flaps. RESULTS: The osseointegration success rate was 92.9%, with a global failure rate (malpositioning or failed osseointegration or loading) of 15%. Failure particularly affected the group of irradiated patients and those subjected to lateral osseomyocutaneous trapezial pedicled flap reconstruction. Excellent results were obtained with the fibular and iliac crest free flaps and osseointegrated dental implants. CONCLUSIONS: The difficulties of prosthetic rehabilitation are discussed, along with the individualized solutions applied, the repercussions on the temporomandibular joint, and the management protocol adopted by our service.

PMID: 19837322 [PubMed - indexed for MEDLINE]

Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate

Posted: January 11th, 2010, 9:00am CST

Condition: Rare Tumor
Interventions: Drug: Imatinib mesylate, Cyclophosphamide (Dosing level 1 ); Drug: Imatinib mesylate, Cyclophosphamide (Dosing level 2); Drug: Imatinib mesylate, Cyclophosphamide (Dosing level 3); Procedure: Blood sampling
Sponsor: Centre Oscar Lambret
Active, not recruiting - verified January 2010

1 2 3 ... 28

Rare Cancer News

Feeds

Unread items (100)

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 21st, 2010, 6:02pm CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: December 27th, 2009, 9:49am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 21st, 2010, 6:02pm CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 10th, 2010, 2:29pm CST

Fetched: January 10th, 2010, 2:29pm CST

Fetched: January 10th, 2010, 2:29pm CST

Fetched: January 10th, 2010, 2:29pm CST

Fetched: December 27th, 2009, 9:49am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 22nd, 2009, 8:01am CST

Fetched: December 9th, 2009, 7:36am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Fetched: November 27th, 2009, 11:17am CST

Posted: January 25th, 2010, 2:12am CST

Posted: January 24th, 2010, 9:21am CST

Posted: January 22nd, 2010, 8:20pm CST

Posted: January 21st, 2010, 3:50am CST

Posted: January 18th, 2010, 1:24pm CST

Posted: January 12th, 2010, 9:46pm CST

Posted: December 25th, 2009, 2:09am CST

Posted: December 18th, 2009, 9:11am CST

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 31st, 2010, 3:49pm CST

Fetched: January 21st, 2010, 6:02pm CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 20th, 2010, 9:02am CST

Fetched: January 10th, 2010, 2:29pm CST

Fetched: January 3rd, 2010, 8:22pm CST

Fetched: January 1st, 2010, 4:55pm CST

Fetched: January 1st, 2010, 4:55pm CST

Fetched: January 1st, 2010, 4:55pm CST